MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration

作者：Mitja M. Zdouc, Kai Blin, Nico L L Louwen, Jorge C. Navarro-Muñoz, Catarina Loureiro, Chantal D. Bader, Constance B. Bailey, Lena Barra, Thomas Booth, Kenan A. J. Bozhüyük, José D D Cediel-Becerra, Zachary Charlop–Powers, Marc G. Chevrette, Yit‐Heng Chooi, Paul M. D’Agostino, Tristan de Rond, Elena Del Pup, Katherine Duncan, Wenjia Gu, Novriyandi Hanif, Eric J. N. Helfrich, Matthew Jenner, Yohei Katsuyama, Aleksandra Korenskaia, Daniel Krug, Vincent Libis, George Lund, Shrikant Mantri, Kalindi D. Morgan, Charlotte Owen, Chin‐Soon Phan, Benjamin Philmus, Zachary L. Reitz, Serina L. Robinson, Kumar Saurabh Singh, Robin Teufel, Yaojun Tong, Fidele Tugizimana, Dana Ulanová, Jaclyn M. Winter, César Aguilar, Daniel Yuri Akiyama, Suhad A. A. Al-Salihi, Mohammad Alanjary, Fabrizio Alberti, Gajender Aleti, Shumukh A. Alharthi, Mariela Y Arias Rojo, Amr A. Arishi, Hannah E. Augustijn, Nicole E. Avalon, J. Abraham Avelar‐Rivas, Kyle K. Axt, Hellen Bertoletti Barbieri, Júlio César Jerônimo Barbosa, Lucas Gabriel Barboza Segato, Susanna E. Barrett, Martin Baunach, Christine Beemelmanns, Dardan Beqaj, Tim Berger, Jordan Bernaldo-Agüero, Sandra M Bettenbühl, Vincent A. Bielinski, Friederike Biermann, Ricardo Moraes Borges, Rainer Borriss, Milena Breitenbach, Kevin M. Bretscher, Michael W Brigham, Larissa Buedenbender, Brodie W. Bulcock, Carolina Cano‐Prieto, João Capela, Víctor J. Carrión, Riley S. Carter, Raquel Castelo‐Branco, Gabriel Castro‐Falcón, Fernanda O. Chagas, Esteban Charria‐Girón, Ayesha Ahmed Chaudhri, Vasvi Chaudhry, Hyukjae Choi, Yukyung Choi, Roya Choupannejad, Jakub Chromy, Melinda S. Chue Donahey, Jérôme Collemare, Jack A Connolly, Kaitlin E. Creamer, Max Crüsemann, Arturo Colín-Cruz, Andrés Cumsille, Jean‐Félix Dallery, Luis Caleb Damas-Ramos, Tito Damiani, Martinus de Kruijff, Belén Martín, Gerardo Della Sala, Jelle Dillen, Drew T Doering, Shravan R. Dommaraju, Suhan Durusu, Susan Egbert, Mark Ellerhorst, Baptiste Faussurier, Artem Fetter, Marc Feuermann, David P. Fewer, Jonathan Foldi, Andri Frediansyah, Erin Garza, Athina Gavriilidou, Andrea Gentile, Jennifer Gerke, Hans Gerstmans, Juan Pablo Gomez‐Escribano, Luz Ángela González-Salazar, Natalie E Grayson, Claudio Greco, Juan E Gris Gomez, Sebastian Guerra, Shaday Guerrero Flores, Alexey Gurevich, Karina Gutiérrez-García, Lauren Hart, Kristina Haslinger, Beibei He, Téo Hebra, Jethro L. Hemmann, Hindra Hindra, Lars Höing, Darren C. Holland, Jonathan E Holme, Therese Horch, Pavlo Hrab, Jie Hu, Thanh‐Hau Huynh, Ji-Yeon Hwang, Riccardo Iacovelli, Dumitrita Iftime, Marianna Iorio, Sidharth Jayachandran, Eunah Jeong, Jiayi Jing, Jin‐A Jung, Yuya Kakumu, Edward Kalkreuter, Kyo Bin Kang, Sangwook Kang, Wonyong Kim, Geum Jin Kim, Hyun Woo Kim, Hyun Uk Kim, Martin Klapper, Robert A. Koetsier, Cassandra Kollten, Ákos T. Kovács, Yelizaveta Kriukova, Noel Kubach, Aditya M. Kunjapur, Aleksandra Kushnareva, Andreja Kust, Jessica Lamber, Martin Larralde, Niels Juul Larsen, Adrien P Launay, Ngoc-Thao-Hien Le, Sarah Lebeer, Byung Tae Lee, Kyungha Lee, Katherine L. Lev, Shu-Ming Li, Yong‐Xin Li, Cuauhtémoc Licona‐Cassani, Annette Lien, Jing Liu, Julius Adam V. Lopez, Nataliia V. Machushynets, M. Macı́as, Taifo Mahmud, Matiss Maleckis, Añadir Maharai Martinez-Martinez, Yvonne Mast, Marina Ferreira Maximo, Christina M McBride, Rose M. McLellan, Khyati Bhatt, Chrats Melkonian, Aske Merrild, Mikko Metsä‐Ketelä, Douglas A. Mitchell, Alison V. Müller, Giang‐Son Nguyen, Hera T Nguyen, Timo H. J. Niedermeyer, J. O’Hare, Adam Ossowicki, Bohdan Ostash, Hiroshi Otani, Leo Padva, Sunaina Paliyal, Xinya Pan, Mohit Panghal, Dana S Parade, Jiyoon Park, Jonathan Parra, M Valera Rubio, Huong T. Pham, Sacha J. Pidot, Jörn Piel, Bita Pourmohsenin, Malik Rakhmanov, Sangeetha Ramesh, Michelle H Rasmussen, Adriana Rego, Raphael Reher, Andrew J. Rice, Augustin Rigolet, Adriana Romero-Otero, Luis Rodrigo Rosas-Becerra, Pablo Y Rosiles, Adriano Rutz, Byeol Ryu, Libby-Ann Sahadeo, Murrel Saldanha, Luca Salvi, Eduardo Sánchez-Carvajal, Christian Santos‐Medellín, Nicolau Sbaraini, Sydney Schoellhorn, Clemens Schumm, Luděk Sehnal, Nelly Sélem, Anjali D Shah, Tânia Keiko Shishido, Simon Sieber, Velina Silviani, Garima Singh, Hemant Singh, Nika Sokolova, Eva C. Sonnenschein, Margherita Sosio, Sven T. Sowa, Karin Steffen, Evi Stegmann, Alena B. Streiff, Alena Strüder, Frank Surup, Tiziana Svenningsen, Douglas Sweeney, Judit Szenei, Azat Tagirdzhanov, Bin Tan, Matthew J. Tarnowski, Barbara R. Terlouw, Thomas Rey, Nicola U. Thome, Laura Rosina Torres Ortega, Thomas Tørring, Marla Trindade, Andrew W. Truman, Marie Selch Tvilum, Daniel Udwary, Christoph Ulbricht, Lisa Vader, Gilles P. van Wezel, Max Walmsley, Randika Warnasinghe, Heiner G Weddeling, Angus N. M. Weir, Katherine Williams, Sam E. Williams, Thomas E. Witte, Steffaney M Wood Rocca, Keith Yamada, Dong Yang, Dongsoo Yang, Jingwei Yu, Zhen‐Yi Zhou, Nadine Ziemert, L. E. Zimmer, Alina Zimmermann, Christian Zimmermann, Justin J. J. van der Hooft, Roger G. Linington, Tilmann Weber, Marnix H. Medema · 发表于：Nucleic Acids Research · 年份：2024 · DOI：10.1093/nar/gkae1115 · 被引用次数：247 · 研究领域：Microbial Natural Products and Biosynthesis、Plant biochemistry and biosynthesis、Microbial Metabolism and Applications

Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is governed by sets of co-regulated and physically clustered genes known as biosynthetic gene clusters (BGCs). To share information about BGCs in a standardized and machine-readable way, the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard and repository was initiated in 2015. Since its conception, MIBiG has been regularly updated to expand data coverage and remain up to date with innovations in natural product research. Here, we describe MIBiG version 4.0, an extensive update to the data repository and the underlying data standard. In a massive community annotation effort, 267 contributors performed 8304 edits, creating 557 new entries and modifying 590 existing entries, resulting in a new total of 3059 curated entries in MIBiG. Particular attention was paid to ensuring high data quality, with automated data validation using a newly developed custom submission portal prototype, paired with a novel peer-reviewing model. MIBiG 4.0 also takes steps towards a rolling release model and a broader involvement of the scientific community. MIBiG 4.0 is accessible online at https://mibig.secondarymetabolites.org/.