Metal-Free Synthesis of Functionalized Indolizines via a Cascade Michael/S N 2/Aromatization Reaction of 2-Alkylazaarene Derivatives with Bromonitroolefins

作者：Kangbiao Chen, Rui Zhou, Gaofeng Zhu, Lei Tang, Lu Huang, Qing He · 发表于：ACS Omega · 年份：2024 · DOI：10.1021/acsomega.4c09295 · 被引用次数：5 · 研究领域：Synthesis and Reactivity of Heterocycles、Cyclopropane Reaction Mechanisms、Synthesis and Characterization of Pyrroles

2/aromatization annulation of 2-pyridylacetates with bromonitroolefins has been developed. A wide range of substrates containing various substituted groups was compatible with the present methodology and afforded functionalized indolizines with moderate to excellent yield (up to 99% yield). In addition, the potential practicality of the method stood out through scale-up reactions and further transformations to other valuable compounds. In our view, this study is an essential complement for the rapid construction of indolizine derivatives through a metal-free strategy.