Evidence-based guideline: Premature Ovarian Insufficiency

作者：Ladan Yeganeh, Rinky Giri, Madeline Flanagan, Nick Panay, Richard A. Anderson, Amy Bennie, Marcelle Ivonne Cedars, Melanie C. Davies, Carolyn Ee, Claus Højbjerg Gravholt, Sophia Kalantaridou, Amanda Nicole Kallen, Kimberly Q Kim, Micheline Misrahi, Aya Mousa, Rossella Elena Nappi, Walter A. Rocca, Xiangyan Ruan, Helena Jane Teede, Nathalie Vermeulen, Elinor Vogt, Amanda J. Vincent · 发表于：Fertility and Sterility · 年份：2024 · DOI：10.1016/j.fertnstert.2024.11.007 · 被引用次数：76 · 研究领域：Menopause: Health Impacts and Treatments、Ovarian function and disorders、Reproductive Biology and Fertility

STUDY QUESTION: How should premature/primary ovarian insufficiency (POI) be diagnosed and managed, based on the best available evidence from published literature? SUMMARY ANSWER: The current guideline provides 145 recommendations on symptoms, diagnosis, causation, sequelae and treatment of POI. WHAT IS KNOWN ALREADY: Premature ovarian insufficiency (POI) presents a significant challenge to women's health, with far-reaching implications, both physically and emotionally. The potential implications include adverse effects on quality of life; fertility; and bone, cardiovascular and cognitive health. Although hormone therapy (HT) can mitigate some of these effects, many questions still remain regarding the optimal management of POI. STUDY DESIGN, SIZE, DURATION: , 2024, and written in English were included in the guideline. An integrity review was conducted for the randomised controlled trials (RCTs) on POI included in the guideline. PARTICIPANTS/MATERIALS, SETTING, METHODS: Based on the collected evidence, recommendations were formulated and discussed within the guideline development group until consensus was reached. Women with lived experience of POI informed the recommendations in general, and particularly on those on provision of care. A stakeholder review was organised after finalisation of the draft. The final version was approved by the guideline development group and the ESHRE Executive Committee. MAIN RESULTS AND THE ROLE OF CHANCE: New data indicate a higher prevalence ...