Population-based active surveillance of pertussis hospitalization rates in two cities of China

作者：Hanying Dai, Hanqing He, Yanyang Zhang, Juan Xu, Jie Che, Yao Zhu, Tao Fu, Chuanwei Chen, Qian Zhou, Bohan Chen, Yuan Gao, Aiping Qin, Maojun Zhang, Zhujun Shao · 发表于：European Journal of Clinical Microbiology & Infectious Diseases · 年份：2024 · DOI：10.1007/s10096-024-05001-8 · 被引用次数：6 · 研究领域：Bacterial Infections and Vaccines、Vaccine Coverage and Hesitancy、Pneumonia and Respiratory Infections

PURPOSE: Hospitalization is most common for severe pertussis cases and those with serious complications caused by pertussis. In mainland China, the immunization program consists of primary vaccinations at 3, 4, and 5 months, followed by a booster at 18 months with DTaP. It remains uncertain whether the first dose at 3 months, rather than 6 weeks as WHO recommended, may increase disease burden, as delayed immunization may lead to lagged protection. This study aimed to determine pertussis hospitalization rates by active surveillance in China, shedding light on immunization strategies for better disease control. METHODS: From June 1, 2021, to May 31, 2022, two Chinese cities underwent a population-based active surveillance. Suspected pertussis cases were confirmed as pertussis cases through PCR and culture. Pertussis hospitalization rates were calculated by dividing the number of laboratory confirmed pertussis cases by the hospitalization coverage rate of surveillance hospitals and the resident population. RESULTS: During the study period 2021-2022, pertussis hospitalization rate in Yiwu was 2.50/100,000 (95% CrI 2.48-2.53), while in Yongcheng, it was 7.90/100,000 (95% CrI 7.81-8.00). In both cities, infants aged < 1 year had the highest hospitalization rate (215.64/100,000: Yiwu; 217.65/100,000: Yongcheng), followed by the age group of 4-5 years (16.37/100,000: Yiwu; 65.70/100,000: Yongcheng). CONCLUSIONS: This study revealed significant pertussis hospitalization rates in China...