Decarboxylative Coupling of Ketoacids with Allylic Acetates

作者：Xiaoyu Zhang, Fanyi Hou, Yinlei Zhang, Bowen Li, Peizhong Xie, Teck‐Peng Loh · 发表于：Organic Letters · 年份：2024 · DOI：10.1021/acs.orglett.4c03514 · 被引用次数：2 · 研究领域：Catalytic C–H Functionalization Methods、Synthesis and Catalytic Reactions、Asymmetric Synthesis and Catalysis

We developed a novel, metal-free catalytic system for synthesizing a broad range of itaconates using α-ketoacids and allylic acetate. This method, leveraging phosphine and Mes-Acr + (BF 4 – ) catalysts, has proven versatile, enabling the efficient itaconation of peptides, the synthesis of bioactive itaconates, and the preparation of an itaconate-based bio-orthogonal probe.