Safety, tolerability, pharmacokinetics, and neutralisation activities of the anti-HIV-1 monoclonal antibody PGT121.414.LS administered alone and in combination with VRC07-523LS in adults without HIV in the USA (HVTN 136/HPTN 092): a first-in-human, open-label, randomised controlled phase 1 trial

作者：Srilatha Edupuganti, Christopher B. Hurt, Kathryn E. Stephenson, Yunda Huang, Carmen A. Paez, Chenchen Yu, Catherine Yen, Brett S. Hanscom, Zonglin He, Maurine D. Miner, Theresa Gamble, Jack Heptinstall, Kelly E. Seaton, Elizabeth Domin, Bob C. Lin, Krisha McKee, Nicole A. Doria‐Rose, Stephanie Regenold, Hans M. L. Spiegel, Maija Anderson, Nadia McClosky, Lily Zhang, Estelle Piwowar‐Manning, Margaret E. Ackerman, Michael N. Pensiero, Bonnie J. Dye, Raphael J. Landovitz, Kenneth Hugh Mayer, Marc Siegel, Magdalena E. Sobieszczyk, Stephen R. Walsh, Lúcio Gama, Dan H. Barouch, David C. Montefiori, Georgia D. Tomaras, Cassie Grimsley Ackerley, Daniel S. Graciaa, Colleen Frances Kelley, Nadine Rouphael, Sharon Curate-Ingram, Bette Korber, Kshitij Wagh, Nandini Sane, Jennifer K. Grossman, Sophie Hasan, Michelle Robinson, Jonathan Paul Lucas, Marianne Reid Gildea, Amber Babinec, Bethany Coomes, Julie B. Dumond, Justine Beck, Wairimu Chege, Xue Han, Jen Hanke, Carissa Karg, Laurie Rinn, Miriam Chicurel-Bayard, Shashikala Nagar, H. Steve White, William A. Cooley, Gail B. Broder, Machel Hunt, Vanessa Cummings, Kristine Donaty, April Kaur Randhawa, Ramey Fair, Noshima Y Darden‐tabb, Richa Chaturvedi, Lindsey Robert Baden, Amy C Sherman, Jon A Gothing, Andres A Avila Paz, Julia Klopfer, Megan M. Powell, Anna Piermattei, August Heithoff, Joshua A. Weiner, Gabriela Kovacikova, Katherine S. Axelrod, Lu Zhang, Saman Baral, Nicole L. Yates, Kelvin T. Chiong, Irene C. Kuo, Jeanne A. Jordan, Madison Lintner, Kayley Langlands, Bitana Saintilma, Hannah Yellin, Madhu Balachandran, Manya Magnus, Jane A. Gwira Baumblatt, India Tindale, Samantha Fortier, Aleen Khodabakhshian, Nick Pierce, Maricela Gonzalez, L. Lawrence Mark, Melinda Kuo, Ste'von Afemata · 发表于：The Lancet HIV · 年份：2024 · DOI：10.1016/s2352-3018(24)00247-9 · 被引用次数：12 · 研究领域：HIV Research and Treatment、HIV/AIDS drug development and treatment、Monoclonal and Polyclonal Antibodies Research