Superoxide dismutase promotes gastric tumorigenesis mediated by Helicobacter pylori and enhances resistance to 5-fluorouracil in gastric cancer

作者：Hongbing Fu, Yu Zhang, Yantao Duan, Xin Zhang, Jun Yao, Dejun Yang, Ziran Wei, Zhenxin Zhu, Jiapeng Xu, Zunqi Hu, Qing You, Ronglin Yan, Weijun Wang · 发表于：iScience · 年份：2024 · DOI：10.1016/j.isci.2024.111553 · 被引用次数：8 · 研究领域：Helicobacter pylori-related gastroenterology studies、Gastric Cancer Management and Outcomes、Cancer-related molecular mechanisms research

can promote gastric carcinogenesis by activating the NF-κB/SOD2/AKT/GPX4 pathway, leading to the inhibition of ferroptosis. This may provide a promising therapeutic target for GC.