The Role and Applied Value of Mitochondria in Glioma‐Related Research

作者：Liwen Chen, Hui Zhang, Chao Shang, Yang Hong · 发表于：CNS Neuroscience & Therapeutics · 年份：2024 · DOI：10.1111/cns.70121 · 被引用次数：16 · 研究领域：Mitochondrial Function and Pathology、Cancer, Hypoxia, and Metabolism、Glioma Diagnosis and Treatment

Mitochondria, known as the "energy factory" of cells, are essential organelles with a double membrane structure and genetic material found in most eukaryotic cells. They play a crucial role in tumorigenesis and development, with alterations in mitochondrial structure and function in tumor cells leading to characteristics such as rapid proliferation, invasion, and drug resistance. Glioma, the most common brain tumor with a high recurrence rate and limited treatment options, has been linked to changes in mitochondrial structure and function. This review focuses on the bioenergetics, dynamics, metastasis, and autophagy of mitochondria in relation to glioma proliferation, as well as the potential use of mitochondria-targeting drugs in glioma treatment.