Worldwide patterns and trends in ovarian cancer incidence by histological subtype: a population-based analysis from 1988 to 2017

作者：Yifan Wei, Ning Li, Yilin Xu, Jing Ma, Li D, Zan-Fei Feng, Fanghua Liu, Yi-Zi Li, He-Li Xu, Peng Li, Yong-Pei Yu, Donghui Huang, Xiao-Ying Li, Song Gao, Chunqing Lin, Ting‐Ting Gong, Qi‐Jun Wu, Jinghe Lang · 发表于：EClinicalMedicine · 年份：2024 · DOI：10.1016/j.eclinm.2024.102983 · 被引用次数：31 · 研究领域：Ovarian cancer diagnosis and treatment、PARP inhibition in cancer therapy、Ferroptosis and cancer prognosis

Background: Ovarian cancer (OC) is a heterogeneous malignancy with multiple histological subtypes, showing global variability in incidence. Temporal changes in diagnostic criteria and risk factors might influence the incidence and distribution of OC and its subtypes. Methods: This study analyzed incidence patterns (2013-2017) and trends (1988-1992 to 2013-2017) of OC and its subtypes across 65 and 40 countries, respectively. Data were extracted from the Cancer Incidence in Five Continents (CI5 Ⅻ) and CI5plus databases (accessed in June 2024). Annual percent changes were computed to describe trends in age-standardized rates (ASRs) of OC and its subtypes. Proportions of ASR for each subtype relative to the ASR of OC for individual countries were calculated. Findings: The incidence of OC displayed marked disparities across regions and Human Development Index (HDI), with the highest ASRs in Eastern and Central Europe and very high HDI regions, and the lowest in Africa, Asia, and medium HDI regions. Despite stable trend in ASRs of OC globally, notable declines were observed in Europe, America, and Oceania, in contrast to increases in Asian countries like Japan and South Korea. Globally, serous carcinomas remained the most prevalent subtype. European countries exhibited a higher proportion of serous carcinomas, while Asian countries had a higher proportion of endometrioid and clear cell carcinomas. Although trends in subtypes also remained stable, ASRs increased over time for serou...