Effectiveness of non-pharmacological interventions in managing symptom clusters among lung cancer patients: a systematic review

作者：Qiuhong Chen, Yonglin Li, Yiyang Lin, Xiujing Lin, Rachel Arbing, Wei‐Ti Chen, Feifei Huang · 发表于：BMC Cancer · 年份：2024 · DOI：10.1186/s12885-024-13246-x · 被引用次数：7 · 研究领域：Cancer survivorship and care、Lung Cancer Treatments and Mutations、Cancer-related cognitive impairment studies

Abstract Background Non-pharmacological interventions, as complements to pharmacological treatments, are widely employed for managing symptom clusters in patients with lung cancer. Although numerous systematic reviews and meta-analyses have explored the effects of these interventions, most studies have centred on the broader cancer population and specific symptom clusters. This review aims to consolidate existing non-pharmacological interventions and assess their effectiveness in managing symptom clusters among lung cancer patients. Methods A comprehensive literature search, encompassing eight databases from inception to October 1, 2024, was conducted. Two independent reviewers carried out the study selection, quality assessment, and data extraction. Methodological quality was evaluated using the Cochrane Risk-of-Bias 2 tool and the Risk of Bias in Non-randomized Studies of Interventions. The findings were synthesized narratively based on intervention type and supplemented by meta-analysis using RevMan 5.4 software. The study protocol was registered with PROSPERO (CRD42023467406). Results This systematic review comprised 15 relevant studies involving 1,692 patients, published between 2011 and 2024. The analysis revealed the effectiveness of psychological, educational, and complementary or alternative medicine interventions in alleviating the severity of most symptom clusters. However, the efficacy of exercise-based and multimodal interventions remained inconclusive. The meta-...