High‐Performance Cooperative DNA Nanodevice Enables Sensitive Circular RNA Imaging and Precise Tumor Growth Suppression

作者：Ye Zhang, Siting Chen, Shihua Luo, Wenbin Li, Lifeng Zhang, Fei Lan, Yitong Zhu, Huijun Du, Ke Li, Chunchen Liu, Bo Situ, Bo Li, Xiaohui Yan · 发表于：Small Structures · 年份：2024 · DOI：10.1002/sstr.202470061 · 被引用次数：19 · 研究领域：Circular RNAs in diseases、RNA Research and Splicing、MicroRNA in disease regulation

High-Performance Cooperative DNA Nanodevices In article number 2400255, Ye Zhang, Xiaohui Yan, and co-workers report a high-performance cooperative DNA nanodevice for sensitive imaging and precise regulation of circRNAs. With a cooperative exponential signal amplification, the nanodevice effectively detects minute quantities of circRNAs with negligible background interference. It also promotes tumor cell apoptosis and inhibits tumor growth by preloading tumor suppression miRNAs and so can serve as a potential tool box in clinical tumor diagnosis and therapy.