Chronic pancreatitis

作者：Naomi D. E. Thierens, Robert C. Verdonk, Matthias J. Löhr, Hjalmar C. van Santvoort, Stefan A.W. Bouwense, Jeanin Elise van Hooft · 发表于：The Lancet · 年份：2024 · DOI：10.1016/s0140-6736(24)02187-1 · 被引用次数：77 · 研究领域：Pancreatitis Pathology and Treatment、Gastrointestinal disorders and treatments、Pancreatic and Hepatic Oncology Research

Chronic pancreatitis is a progressive fibroinflammatory disease primarily caused by a complex interplay of environmental and genetic risk factors. It might result in pancreatic exocrine and endocrine insufficiency, chronic pain, reduced quality of life, and increased mortality. The diagnosis is based on the presence of typical symptoms and multiple morphological manifestations of the pancreas, including pancreatic duct stones and strictures, parenchymal calcifications, and pseudocysts. Management of chronic pancreatitis consists of prevention and treatment of complications, requiring a multidisciplinary approach focusing on lifestyle modifications, exocrine insufficiency, nutritional status, bone health, endocrine insufficiency, pain management, and psychological care. To optimise clinical outcomes, screening for complications and evaluation of treatment efficacy are indicated in all patients with chronic pancreatitis.