Associations of long-term nitrogen dioxide exposure with a wide spectrum of diseases: a prospective cohort study of 0·5 million Chinese adults

作者：Xi Xia, Xia Meng, Cong Liu, Yi Guo, Xinyue Li, Yue Niu, Hubert Lam, Neil Wright, Christiana Kartsonaki, Yiping Chen, Ling Yang, Huaidong Du, Canqing Yu, Dianjianyi Sun, Jun Lv, Junshi Chen, Xiaoming Yang, Ruqin Gao, Shaowei Wu, Shaowei Wu, Haidong Kan, Ka Hung Chan, Zhengming Chen, Liming Li, Zhengming Chen, Junshi Chen, Zhengming Chen, Robert Clarke, Rory Collins, Liming Li, Jun Lv, Richard Peto, Robin Walters, Ahmed EdrisMohamed, Alfred Pozarickij, Andri Iona, Baihan Wang, Charlotte Clarke, Christiana Kartsonaki, Dan Schmidt, Daniel Avery, Derrick Bennett, Hannah Fry, Huaidong Du, Hubert Lam, Iain Turnbull, Iona Millwood, James Liu, Jonathan Clarke, Ka Hung Chan, Ka Hung Chan, Kshitij Kolhe, Kuang Lin, Lin Wang, Ling Yang, Maria Kakkoura, Maryam Rahmati, Maxim Barnard, Mohsen Mazidi, Neil Wright, Pang Yao, Paul Ryder, Pek Kei Im, Prapthi Harish, Qunhua Nie, Rebecca Stevens, Robert Clarke, Robin Walters, Ruth Boxall, Sam Morris, Simon Gilbert, Xiaoming Yang, Yiping Chen, Zhengming Chen, Xiao Han, Can Hou, Qingmei Xia, Chao Liu, Jun Lv, Pei Pei, Dianjianyi Sun, Canqing Yu, Lang Pan, Zengchang Pang, Ruiqin Gao, Shanpeng Li, Haiping Duan, Shaojie Wang, Yongmei Liu, Ranran Du, Yajing Zang, Liang Cheng, Xiaocao Tian, Hua Zhang, Yaoming Zhai, Feng Ning, Xiaohui Sun, Feifei Li, Silu Lv, Junzheng Wang, Wei Hou, Wei Sun, Shichun Yan, Xiaoming Cui, Chi Wang, Zhenyuan Wu, Yanjie Li, Quan Kang, Huiming Luo, Tingting Qu, Xiangyang Zheng, Zhendong Guo, Shukuan Wu, Shukuan Wu, Yilei Li, Huimei Li, Ming Wu, Yonglin Zhou, Jinyi Zhou, Ran Tao, Jie Yang, Jian Su, Fang Liu, Jun Zhang, Yihe Hu, Yan Lu, Liangcai Ma, Aiyu Tang, Shuo Zhang, Jianrong Jin, Jingchao Liu, Mei Lin, Zhenzhen Lu, Lifang Zhou, Changping Xie, Jian Lan, Tingping Zhu, Yun Liu, Liuping Wei, Liyuan Zhou, Ningyu Chen, Yulu Qin, Sisi Wang, Xiangping Wu, Ningmei Zhang, Xiaofang Chen, Xiaoyu Chang, Mingqiang Yuan, Xia Wu, Xiaofang Chen, Wei Jiang, Jiaqiu Liu, Qiang Sun, Faqing Chen, Xiaolan Ren, Caixia Dong, Hui Zhang, Enke Mao, Xiaoping Wang, Tao Wang, Xi Zhang, Kai Kang, Shixian Feng, Huizi Tian, Lei Fan, Xiaolin Li, Huarong Sun, Pan He, Xukui Zhang, Min Yu, Ruying Hu, Hao Wang, Xiaoyi Zhang, Yuan Cao, Kaixu Xie, Lingli Chen, Dun Shen, Xiaojun Li, Donghui Jin, Li Yin, Huilin Liu, Zhongxi Fu, Xin Xu, Hao Zhang, Jianwei Chen, Yuan Peng, Libo Zhang, Chan Qu · 发表于：The Lancet Public Health · 年份：2024 · DOI：10.1016/s2468-2667(24)00264-0 · 被引用次数：31 · 研究领域：Air Quality and Health Impacts、Energy and Environment Impacts、Health, Environment, Cognitive Aging

Background Little evidence is available on the long-term health effects of nitrogen dioxide (NO 2 ) in low-income and middle-income populations. We investigated the associations of long-term NO 2 exposure with the incidence of a wide spectrum of disease outcomes, based on data from the China Kadoorie Biobank. Methods This prospective cohort study involved 512 724 Chinese adults aged 30–79 years recruited from ten areas of China during 2004–08. Time-varying Cox regression models yielded adjusted hazard ratios (HRs) for the associations of long-term NO 2 exposure with aggregated disease incidence endpoints classified by 14 ICD-10 chapters, and incidences of 12 specific diseases selected from three key ICD-10 chapters (cardiovascular, respiratory, and musculoskeletal diseases) found to be robustly associated with NO 2 in the analyses of aggregated endpoints. All models were stratified by age-at-risk (in 1-year scale), study area, and sex, and were adjusted for education, household income, smoking status, alcohol intake, cooking fuel type, heating fuel type, self-reported health status, BMI, physical activity level, temperature, and relative humidity. Findings The analysis of 512 709 participants (mean baseline age 52·0 years [SD 10·7]; 59·0% female and 41·0% male) included approximately 6·5 million person-years of follow-up. Between 5285 and 144 852 incident events were recorded for each of the 14 aggregated endpoints. Each 10 μg/m 3 higher annual average NO 2 exposure was assoc...