Best Practices for Delivering Neoadjuvant Therapy in Pancreatic Ductal Adenocarcinoma

作者：Jordan M. Cloyd, Angela Sarna, Matthew J. Arango, Susan E. Bates, Manoop S. Bhutani, Mark Bloomston, Vincent M. Chung, Efrat Dotan, Cristina R. Ferrone, Patricia Gambino, Ajit Harishkumar Goenka, Karyn A. Goodman, William Adrian Hall, Jing He, Melissa Ellen Hogg, Shiva Jayaraman, Avinash Kambadakone, Matthew H. G. Katz, Alok A. Khorana, Andrew H. Ko, Eugene Jon Koay, David A. Kooby, Somashekar G. Krishna, Liliana K. Larsson, Richard Tsong Lee, Anirban Maitra, Nader Nabile Massarweh, Sameh Mikhail, Mahvish Muzaffar, Eileen Mary O'Reilly, Manisha Palta, Maria Q. B. Petzel, P. A. Philip, Marsha Reyngold, Daniel Santa Mina, Davendra P. S. Sohal, Tilak Kumar Sundaresan, Susan Tsai, Kea L. Turner, Timothy J. Vreeland, Steve Walston, Mary Kay Washington, Terence Marques Williams, Jennifer Yon-Li Wo, Rebecca A. Snyder · 发表于：JAMA Surgery · 年份：2024 · DOI：10.1001/jamasurg.2024.5191 · 被引用次数：16 · 研究领域：Pancreatic and Hepatic Oncology Research、Esophageal Cancer Research and Treatment、Pancreatitis Pathology and Treatment

Importance: Neoadjuvant therapy (NT) is an increasingly used treatment strategy for patients with localized pancreatic ductal adenocarcinoma (PDAC). Little research has been conducted on cancer care delivery during NT, and the standards for optimal delivery of NT have not been defined. Objective: To develop consensus best practices for delivering NT to patients with localized PDAC. Design, Setting, and Participants: This study used a modified Delphi approach consisting of 2 rounds of voting, and a series of virtual conferences (from October to December 2023) to reach expert consensus on candidate best practice statements generated from a systematic review of the literature and expert opinion. An interdisciplinary panel was formed including 47 North American experts from surgical, medical, and radiation oncology, radiology, pathology, gastroenterology, integrative oncology, anesthesia, pharmacy, nursing, cancer care delivery research, and nutrition as well as patient and caregiver stakeholders. Main Outcome and Measures: Statements that reached 75% agreement or greater were included in final consensus statements. Results: Of the 47 participating panel members, 27 (57.64%) were male, and the mean (SD) age was 47.6 (8.2) years. Physicians reported completing training a mean (SD) 14.6 (8.6) years prior and seeing a mean (SD) 110.6 (38.4) patients with PDAC annually; 35 (77.7%) were in academic practice. Final consensus was reached on 82 best practices for delivering NT. Of these,...