Tranexamic acid versus placebo to prevent bleeding in patients with haematological malignancies and severe thrombocytopenia (TREATT): a randomised, double-blind, parallel, phase 3 superiority trial

作者：Lise J Estcourt, Zoe McQuilten, Peter Bardy, Merrole Cole‐Sinclair, Graham P. Collins, Philip Crispin, Elinor Curnow, Jennifer Curnow, Amber Degelia, Claire Dyer, Adam Friebe, Lajos Flóró, Effie Grand, Cara Hudson, Gail Jones, Joanne Joseph, Charlotte Kallmeyer, Μαρίνα Καρακάντζα, Paul M. Kerr, Sara Last, Maria Lobo-Clarke, Matthew Lumley, Mary Frances McMullin, Patrick Medd, Suzy Morton, Andrew Mumford, Maria Mushkbar, Joseph Parsons, Gillian Powter, Mallika Sekhar, Laura Smith, Richard Soutar, William Stevenson, Elango Subramoniapillai, Jeff Szer, Helen Thomas, Neil Waters, Andrew H. Wei, David Westerman, Sarah Wexler, Erica M. Wood, Simon Stanworth, Adrienne Abioye, Rabia Afghan, Sylvia Ai, Magbor Akanni, Rajesh Alajangi, Usmaan Alam, Bahaa Al-Bubseeree, Sophie Alderson, Craig Alderson, Sayed Ali, Kabir Ali, Rookmeen Alighan, Rebecca Allam Allam, Tania Allen, Wesam Al-Sakkaf, Kate Ames, J.O. Anderson, C. J. Andrews, Ann-Marie Angel, Manuela Anlya Anlya, Fazeela Ansari, Rowan Appleby, Claire Arnold, Hulda Ásbjörnsdóttir, Biruk Asfaw, Elissa Atkins, L. Atkinson, Clare Aubrey, Noor Ayesha, Lola Babbola, David R. Badcock, Samuel Badcock, Diva Baggio, Ben Bailiff, Kizzy Baines, Holly Baker, Victoria Baker, Lindsay G. Ball, Martin J. Ball, Irwin Balquin, Emma Banks, George Banos, Jaytee Barnett, Claire Barrie, Claire Barron, Rebecca Barton, Nina Bason, Bindu Batta, Dianne Bautista, Angela Bayley, Emma Bayly, Fionnuala Baynes, Ali Bazargan, Rachel Bazeley, Yvonne Beadle, Claire Beardsmore, Kate Beattie, Kate Beattie, Caroline Bedford, R. Behal, Daniel Behan, L Bejan, Sarah Bell, Karen Bell, Louise Bell, Kaitlyn Bell, Reuben Benjamin, Samuel Bennett, Gary Benson, Warwick Benson, Cameron Bent, Krystal Bergin, Alex Berry, Stephanie Besenyei, Caroline Besley, Scott Betteridge, Leigh Beveridge, Abir Bhattacharyya, Annelies Billen, Ian Bilmon, Emma L. Binns, Mark Birt, D. Timothy Bishop, Andrea Blanco, Lisa Bleby, Richard Blemnerhet, Piers Blombery, Emily Blyth, Nicola M. Blythe, Lauren H. Boal, Ali Boden, Syed Akhtar Hussain Bokhari, Elisa Bongetti, Stephen Booth, Jayne Borley, David E. Bowen, Dawn Bowers, Stephen Boyd, Sarah Bradley, Helen Bradman, Peta Bretag, Maria Brillante, R.A. Brockbank, Yasmin Brough, Ellen Brown, Jo Brown, Eleanor Brown, Claire Brown, Jenny Brown, Susan D. Brown, Joe Browning, Alex Brownsdon, David Bruce, Ruth Brydon-Hill, Andrea Buckwell, D. Burgess, Glenda Burke, Kate Burley, Claire Burney, David Burns, Samuel H. Burrows, Kieran Burton, Jason Butler, Lenka Cambalova, Maria C. Camozzi, Philip Campbell, Karen Campfield, Victoria Campion, Catherine Cargo, Júlia Carmona, Dennis Carney, Joshua Casan, Helen Cashman, Lorraine Catt, Michael J. Cattell, Megan Cavill, Rachel Chadbone, Sridhar Chaganti, Yee Chai, Khai Li Chai, Joshua Chang, Judith Chapman, Oliver G. Chapman, Tamika Chapter, A. J. CHARLTON, Celina Chau, Saleena Rani Chauhan, Nikesh Chavda, Frederick Chen, Melody Chen, Meng Xi Chen, Melanie Chen, Melissa Chen, Kathleen Cheok, Mai Cheung, Luke Chidgey, Karolina Chmielokliec, Philip Choi, Jae Hyuk Choi, Anne Chok, Ruchika Chopra, Louise Christopherson, Vicky Chu, Chong Chyn Chua, Pavel Chudakou, Vidushi Chugh, Chi Ryang Chung, Erin Clark, Peter Clarke, K.W. Clarke, Jennifer Clay, Laura Clayton, Mitch Clements, Jonathan Clemmens, Ruth Clifford, Dave Collett, Maia Collins, Emily Collyer, Maureen Connolly, Mark Cook, Sarah Coombs, Jason Coppell, Sophie Cornwell, Claire Corrigan, Elizabeth Coughlin, Jennifer Couling, Tony Cousins, Catriona Cowan, Christine E. Cox, Catherine Cox, Luke Coyle, Emily Craig, Thomas Creasey, Laura Croan, Jane Croft, Nicola Crosbie, Josephine Crowe, Helen Crowther, Jane Crozier, N. Culleton, Jonathan Cullis, A. M. M. Cumming, Michelle Cummins, Adam F. Cunningham, Cameron Curley, Samantha Curtis, R Cuthbert, Kirsty Cuthill, Dinusha A Dahahayake, Amy Dang, Marc Davies, Ceri Davies, Emily Dawson, Tom Day, Kanchana De Abrew, Hugues de Lavallade, N De Silva, Georgina Dean, Christopher Deane, Lisa Demosthenous, Amisha Desai, Michael Desborough, Ian Devanny, Jay Dhanapal, Sundip Dhani, Vicky Di Martino, Emmy Dickens, Carmen DiCorleto, Louise Dinnett, Divya Dirisan, Karen Dixon, Kiri Dixon, Inderjit Doal, J Dobivh, Maria Docanto, Helve Doecke, David Donaldson, Kylee Donaldson, Carrie Donohoe, A. W. DOUGLAS, Stephen Doung, Susan Downer, James D’Rozario, Malcolm Drummond, Mark Drummond, Samantha Drummond, Elizabeth Drysdale, R M DʼSouza, Eugene D'Souza, Alex Dunn, David Dutton, Martin Dyson, Kushani Ediriwicurena, Sharon Edleston, Dawn Edwards, Morgan R. Edwards, Anita Edwards, Nicole Eise, Steven Ellis, Hayley Ellis, Shareef Elmonley, Rosemarie Enstone, Agnes Eordogh, S. Erb, Shannon Evans, Megan A. Evans, Shannon Evans, Megan A. Evans, Joanne Ewing, Toby A. Eyre, Adam Facey, Mina Fammy, Jon Farman, Rachel Farnell, Laura Del Favero, Keith Fay, Karen Ferguson, Laura Fernon, Robin Filshie, Damian Finnegan, Lisa A. Fisher, A. Flanagan, Emma Fleck, Simon Fletcher, Harpreet Flora, Catherine Flower, Ioana Fodor, Heather Foley, Emma Folland, Comfort Folorunso, Molly Forbes, Katrina Fordwor, Polly Foster, Vanessa Fox, Thomas A. Fox, Olesya Francis, Louise Fryearson, Madonna Fuery, Jiin Fung, Michelle Furtado, Leanne Galloway-Browne, L. Gamble, Jeanette Gamgee, A Ganapathy, Hayley Gardner, Clare Gardner, Noha Gasmelsheed, Amy Gately, Lynda Gaynor, Alex Gebreid, Ruth Geffens, Rachel George, A. Gertner, Manar Ghebeh, Emanuela Ghirardini, Melainie Giddings, Sandra Gillett, Karen Gillett, Pratyush Giri, Chris K. Glass, Sarah Glewis, Sarah Gooding, Olivia Gordon, Joanne Gordon, David Gottlieb, Koushik Gowda, E.W. Gower, Nicola Gray, Jo Grayer, Elaine Greaves, Sally Greenaway, Graeme Greenfield, Matthew Greenwood, Gareth P. Gregory, James E. Griffin, J. P. CROZER GRIFFITH, James Griffith, Lindsey Griffiths, Paulina Grzegrzolka, Yisu Gu, J Guest, Rosanna Guinai, Veena Gullapalli, A. Gunolr, Lina Guo, Howard H. Wayne, Sophia Hagua, Senait Haile, Richard Hall, Maryam Hamdollah‐Zadeh, Zahra Hanif, Kathleen Hanlon, Nicholas Hann, Ramez Hanna, Guy Hannah, Sameera Hapuarachchi, Jacinta Hardman, A. Hardy, Anthony Harris, Kylie Harris, Beth Harrison, Simon J. Harrison, Lea–Anne Harrison, Sean Harrop, Caroline Harvey, Faye Hatcliffe, Joanne Hawking, Matthew Hawkins, Janet Hayden, Michelle Hayman, Elizabeth Haynes, Nicholas Heaney, Andrew I.T. Hebbard, Jenny Hempton, Sasanka Hendunneti, Maeve Henry, Jonathan Heywood, Catherine Hildyard, Lydia Hill, Annette Hilldrith, Petar Hitev, Smita Hiwase, Devendra Hiwase, C. Hoare, Renate Hodge, Amy Holloway, Chloe Holt, Kelly Holton, Lauren Homer, Gillian A. Horne, Noemi Horvath, Linda Hotong, Kristen Houdyk, Katy Houseman, Ilda Hoxhallari, Hannah Hsu, Nina Hsu, Gillian Huang, Kerryn Hudson, Melanie Hufton, Timothy P. Hughes, Siobhan Hughes, K. H. Hurley, Rosie Huxley, Temitope D. Ibitoye, Abubaken Ibrouf, Farha Inam, Tishya Indran, Karen Ingham, Calum Innes, David Irvine, Sarah Jaafar, Manish Jain, Laura Jameson, Pardeep Janjua, Rebecca Jarvis, Abirami Jatheendran, Abbie Javed, Sheila Jen, Shailesh Jobanpura, Irene Jobson, Deborah John, Sophie Johns, Amanda Johnston, Hollie Jones, Francesca M. Jones, Karolina Joniak, Milica Jovanović, Anita Jovic, Lauren Joyce, Andrew Judd, Sudhakar Kakarlamudi, Nick Kakaroubas, Maggie Kalita, Shirly Kam, Julie L.C. Kan, P Kandle, Alex George Kanellopoulos, Chien Kao, Maria Kaparou, Charamlampos Kartsios, Vicki Katsioulas, Russell Kaye, Katie Keen, Richard Kelly, Paul Kelly, Donna Kelly, Melanie E. M. Kelly, Glen Kennedy, Nola Kennedy, Angela Kenny, Zoe Kenworthy, Ian Kerridge, Murali Kesavan, Angelika Khafizi, Muhammad Khakwani, ⁠Amna Khalid, Kate Khamly, Anjum Khan, Dalia Khan, Mojid Khan, Lubna Khan, Mona Khoo, Asim Khwaja, Grace Kim, Andrew King, Vicky King, Donna King, Francesca Kinsella, David Kipp, Pachoo Kirandeep, Laura Chebet Kirui, Bhuvan Kishore, Christopher Knectlhi, Amy Knot, Armit Knot, Clifford Y. Ko, Caitlin Kolaric, Ray Mun Koo, Mary Kotadia, Jaimal Kothari, Panagiotis Kottaridis, Gajan Kuiluinathan, Austin Kulasekararaj, John Kwan, Marwan Kwok, Phillip Kwok, Fiona Kwok, Kristiina Laane, Deena Lad, Jennifer Laird, Ada Lam, Mary Lane, Monica Lanenco, Susan S. Lang, Alex Langridge, Catherine Langton, Michelle Lannon, Annie Latif, Maya Latimer, Ruth Latter, I‐Jun Lau, Sarah Lawless, Theresa Lawless, Mike Leach, Sarah Leaney, Heather Leary, James Leavy, A.-Robert LeBlanc, Vivienne Lee, Edwin Lee, Jenny Lee, T. D. G. Lee, Marian Leischkie, Emma Leitinger, Christopher De Leon, Jayne Leonard, David B. Lewis, Ian Lewis, Tania Lewis, Daniel A. Lim, Kelly Littlewood, Dara Liu, Joanna Loh, Anand Lokare, Anand Lokare, Oliver Lomas, Richard Lovell, Theresa Lowe, Lisa Lowry, Marcin Lubowiecki, Rebecca Lumb, Gail Lynch, Amanda Macaulay, Lyndsey MacDonald, Jill MacDonald-Burn, Margaret L. MacMillan, Karen Maddock, Tomas Mahaliyana, Cassandra Mahon, Alison Maidment, Susie Maier, Michelle Mairos, M. A. Majid, Kenneth Mak, Anne Mak, Arunthrthy Malendrayogau, Hana Malham, Felicity Malyon, Vineela Mandadapu, Laura Mandel, Sarah Mant, Ruth Manton, Nadjoua Maouche, M. A. Maqbool, Gregory Marchant, M. Marinho, David Marks, Mike Marner, Helen Marr, G. Marshall, Siobhan Martin, Abigail Martin, Maria A. V. Marzolini, Katy Mason, Jonathan P. Massie, Rebecca Masson, Vidya Mathavan, Siju Mathew, Judith Mathie, Lehenta Mattocks, Bernard Maybury, Georgina Mayer, Chyrelle McAlister, Jo McAllister, Stewart McConnell, James T. McCracken, Liz McCullagh, Rory McCulloch, Christopher McDermott, K McDonald, Laura McGinniss, Fiona McGurk, Jessica McIlwain, Kirsten McIver, Pam McKay, Lorraine McKenna, Donal P. McLornan, C.G. McMahon, Linda McNeice, S. Alan McNeill, Molly McNickle, Fiona McQueen, Simon McRae, Bobby McTaggart, Jenny Mehew, Varnn Mehra, Michelle Melly, Tara Menichelli, Ken Micklethwatte, Loredana Mihailescue, A Mijović, Hannah Millband, Lucy Miller, Samuel T. Millien, James Milnthorpe, Adrian Minson, Éva Molnár, Marc Monsour, Mary Lynn Moody, Rebecca J Moon, Sally Moore, Katy H. P. Moore, Kelly Morgan, Rebecca Morralley, Denise Morris, Kirk Morris, Nicole Morrison, Merinda Moss, Muhammad Kashif Mughal, Paul Muir, David Mukkath, Aasiyu Mulla, Stephen P. Mulligan, Joanne Mullings, Angela Mulqueen, Caitlin Muluey, Sarah Murdoch, Sura Murrani, Vidhya Murthy, Jimmy Musngi, Nadreen Mustafa, Tracey Mynes, Anastasios Nalpantidis, Harshal Nandurkar, Linda L. Nardone, Latifa Nasari, Latifa Nasari, Monica Nash, Georgina Naylor, Loretta Ngu, Melissa Nguethina, John Nguyen, Joseph Nguyen, W. D. Nichol, E Nicholls, Catherine S. Nicole, Phillip L.R. Nicolson, David L. Nielson, Emmanouil Nikolousis, Georgina Nix, Rita Njoku, Jane E. Norman, Amy M. Norman, Phoebe Norris, Daniel North, M Norwood, Gaynor Notcheva, Igor Novitzky‐Basso, J Nyaboko, Maria Nygren, Ingrid Obu, Siobhan O'Connell, J. Patrick O’Connor, D J Lane O'Kelly, Aideen O'Niell, Jeremy Ony, K Oo, Aung Oo, Anne Oppermann, Anne Oppermann, Ruth Orr, Mary J. O’Sullivan, Jennifer Page, Emma Palfreyman, Shankaranarayana Paneesha, Shyam Panicker, Catherine Parbutt, Elesha Parigi, Gemma Paris, Tracey Parker, C. J. Parnell, Christopher Parrish, Alex Parsons, Mioara Pasat, Natasha Patel, Vijay K. Patel, Pooja Patel, Chaya Patel, Nalini Pati, Andrea Patterson, Lauren A. Paul, Danielle Payet, Elspeth Payne, Victoria Peachey, Amanda Pearson, Andy Peniket, Laura Percy, M.J. Pereyra, Omer Pervaiz, Gunjan Phalod, Anh Pham, Jason Pho, Keir Pickard, Michael Pidcock, Anna Piggin, Anna Piggin, Yalda Pishyar, Abigail Pocock, Ranjendres Pol, Paolo Polzella, Sonia Poolan, Vicki Portingale, Claire Posnett, Sandeep Potluri, Victoria Potter, Guy Pratt, Catherine Prodger, Andres Pueblo, Anish Puliyayil, Pratheepan Puvanakumar, Alam Qadri, Hang Quach, Michael Quinn, Mark Rafferty, Marzia Rahman, Kavita Raj, Sonia Raj, Ramina Rajendran, Radha Ramanan, Karthik Ramasamy, Alexandros Rampotas, Natasha Ranchhod, Sabia Rashid, Sunita Ratanjee, Gurpreet Rathore, Sumita Ratnasingam, Manjit Rayat, Michael Rayner, Rebecca Reddell-Denton, Nicola Redding, Udaya Reddy, Atique Rehman, Carol Rice, I.P. Riches, Thomas Rider, John Riley, Ciro R. Rinaldi, K. Roberts, Andrew W. Roberts, Bryony Robertson, Peter A. Robertson, Dan R. Robinson, Rebecca Robinson, Emma Robjohns, Laura Robledo, Ana Clara Tude Rodrigues, Chris Rofe, Bridie Roff, Rachel Rogers, Jill Rolt, Carmela Rooney, Kathy L Rose, Hannah Rose, David Gaddis Ross, S. Rouf, Claire Rourke, D. Routledge, Janet Ruggiero, Simon Rule, R.D.E. Rumsey, Cherry Sagge, Helen Saldhana, R.E. Salisbury, Sarah Salisbury, Ross Salvaris, Kay Sanders, Mirriam Sangombe, Anna Sanigorska, Kristine Santos, Taylah Sarkis, Anita Sarma, Natalie Saunders, Kara Schmidt, Anja Schmidtmann, Ann Schumacher, Tom Scorer, Asleigh Scott, Ingrid Seath, Frances Sejman, Adrian Selim, Nadia Shamim, Jocelyn Shan, Naranie Shanmuganathan, Shaminie Shanmugaranjan, Michelle Sharpe, Faye Sharpley, Emma Shaw, Cara Sheath, Oonagh Sheehy, Vivian Shen, Solomon Sherbide, Mathew Sheridan, Jane Sheridan, Matthew Sheridon, Tracy Shields, Hau V Sim, Shirlene Sim, Matt Sims, Lydia Singaraveloo, Gurcharan Singh, Jasmine Singh, Shree Sladesal, Andrew Sloan, Peter Slobodian, Sophie Smith, Sarit Smith, Claire Smith, Alastair D. Smith, Neil R. Smith, Katherine Snowden, Joel Solis, Denise Somios, Jade Soo, Michelle M. Spanevello, Madeleie Spaulding, Laura Spence, Liz Spillane, Aimee Spiteri, Naomi S. Sprigg, Sally Springett, Lynn Stafford, Katherine Stainthorp, Kate Stark, Louise Steeden, Ella Stephen, A.L. Stephenson, Andrew Stewart, Orla Stewart, Emma Stobie, Chelsea Stokes, Jacqui Streater, Charlie-Marie Suddens, Surenthini Suntharalingam, Narinder Surana, Robyn M. Sutherland, Antony Sutherland, David Sutton, Connor Sweeney, Reilly Sweet, A. Szücs, Leila Taheri, Hinesh Tailor, Constantine S. Tam, Constantine S. Tam, George Tambakis, Mary Tamplin, Chee-Wee Tan, Sui Tan, Joanne B.L. Tan, Zhi Tan, T Taran, Fiona Tarpey, Angela Taseka, Suzy Tasker, Maciej Tatarczuch, Sarrah Tayabali, Hannah Taylor, Robert W. Taylor, Melaine Taylor, Ella Taylor-Moore, L. Teasdale, Elizabeth Tebbet, Aditya Tedjasepstra, Aditya Tedjaseputra, Oummy Tepkumkun, Andrew Terpstra, Wayne Thomas, Shanice Thomas, Rachel Thompson, Thomas Thornton, Bronwyn Thorp, Moi Yap Thrift, Phillipa Thwaites, Jasmine Timbres, Lauren Tindall, Ing Soo Tiong, Nicole Tippler, Tony Todd, Shirley Todd, Neil Toghill, E. Tomlinson, J A Tooth, Max S. Topp, Nicola Trail, Nguyen Tran, Elizabeth Tran, Vi Tran, Bona Treder, Michelle Tribbeck, Siobhan Trochowski, Maria Truslove, Tsun Tse, Bing Tseu, David Tucker, Kelly Turner, Dianne Turner, Kelly Turner, Herleen Turner, Gillian Turner, Julie Twohig, Thomas Tylee, Micheleine Uhe, Lauren Underhill, Verheij Joanne, Georgina Van der Vliet, Tina van Tonder, Carrie VanderWeyden, Jerry Varghese, Lachlan Vaughan, David Veale, Nicky Vickaryyous, K G Vince, Jacoba Von Welligh, Sona Vora, Sona Vora, Karan Wadehra, Rebecca Walker, Stephen Walker, Roslyn Wallace, Stephanie Wallniosve, S. Wallwork, Zoe Walmsley, Fiona Walters, Yuexin Wang, Angela Wang, Wang Chen, Mercy Wanyika, Dana Warcel, Katrina Wardrobe, Kristian Warnes, Christopher C. M. Waterhouse, Adam Waterworth, Caroline Watson, Edmund Watson, Emily Watts, Emma Weaver, N Weber, Kaytie Webley, Amy Welford, Matt Wells, Sarah K. Westbury, Jackie Westcott, Robyn Western, J. Weston, Jessica A. White, Phillipa C. White, Anna Whitehead, James Whitehouse, Samantha Wieringa, John Willan, Sandra Williams, Bethany Williams, Stephanie Williamson, Brett Willoughby, Gail Wilmot, Rosalind Wilmott, Joanna Wilson, Emma Wilson, Suzy Wilson, Heather Wilson‐Robles, Caroline Wilson, Tanya Wilson, Margaret Wilton, Paula Wiltshire, Joanne Wincup, Julia Wolf, Henna Wong, Cyndi Wong, Daniel Wong, Jonathan W.C. Wong, Shi Qin Wong, Sarah Wood, Henry M. Wood, Jackie Wooding, Kelly Woolley, Myles Wright, Myles Wright, Roland Wynn-Williams, Costas K. Yannakou, Zhi Han Yeoh, Zhi Han Yeoh, David T Yeung, Agnes Young, Flora Yuen, Agnes Yuen, Orjena Žaja, Xiaoyin Zhang, Mei Zhang · 发表于：The Lancet Haematology · 年份：2024 · DOI：10.1016/s2352-3026(24)00317-x · 被引用次数：14 · 研究领域：Blood transfusion and management、Inflammatory Biomarkers in Disease Prognosis、Platelet Disorders and Treatments