Visible-Light-Mediated Benzylic Oxidation Using Bromo(diphenyl) methane

作者：Ying‐Lung Steve Tse, Ying‐Yeung Yeung, Ka-Mei Lee, H. Wong, Sze‐Yung Wong, Yung‐Yin Chan · 发表于：Synlett · 年份：2024 · DOI：10.1055/a-2495-3429 · 研究领域：Oxidative Organic Chemistry Reactions、Radical Photochemical Reactions、Neurological Disease Mechanisms and Treatments

Abstract Benzylic C(sp3)–H oxidation is a useful process that can give aryl carbonyl compounds as valuable building blocks. Here, we report a study on the use of bromo(diphenyl)methane as a Br source for a phototriggered benzylic oxidation. The reaction conditions are mild and compatible with a variety of substrates. Mechanistic studies suggest that the reaction might involve a peroxyl radical intermediate formed by a reaction between a benzylic C radical and molecular oxygen.