Age-related clonal hematopoiesis and HIV infection are associated with geriatric outcomes: The ARCHIVE study

作者：Win Min Han, Hossain M. S. Sazzad, Mark Bloch, David Baker, Norman Roth, Ellen Bowden-Reid, Don Smith, Jennifer Hoy, Ian Woolley, Robert Finlayson, David J. Templeton, Gail Matthews, Jane Costello, Mark A. Dawson, Sarah‐Jane Dawson, Mark N. Polizzotto, Kathy Petoumenos, Paul Yeh, Nila J. Dharan, Win Min Han, Hossain M.S. Sazzad, Mark Bloch, Diana Winter, David Baker, Norman Roth, Helen Lau, Don Smith, Kathryn Acklom, Jennifer F. Hoy, Sally Price, Ian Woolley, Jessica O’Bryan, Robert Finlayson, David J. Templeton, Brett Sinclair, Gail Matthews, Jane Costello, Mark A. Dawson, Sarah-Jane Dawson, Mark N. Polizzotto, Kathy Petoumenos, Paul Yeh, Nila J. Dharan · 发表于：Cell Reports Medicine · 年份：2024 · DOI：10.1016/j.xcrm.2024.101835 · 被引用次数：3 · 研究领域：HIV-related health complications and treatments、Bone and Joint Diseases、Acute Myeloid Leukemia Research

While HIV infection and clonal hematopoiesis (CH) have been linked with inflammatory dysregulation and an increased risk of aging-related comorbidities, their relationship with clinical geriatric syndromes has not been well defined. In the Age-related Clonal Haematopoiesis in an HIV Evaluation Cohort (ARCHIVE) study (NCT04641013), we measure associations between HIV and CH and geriatric syndromes. Of 345 participants (176 with HIV and 169 without HIV), 23% had at least one mutation associated with CH: 27% with HIV and 18% without HIV (p = 0.048). In adjusted analyses, HIV infection is independently associated with increased phenotypic age acceleration (coefficient 1.73, 95% confidence interval [CI] 0.3, 3.16) and CH is independently associated with being frail (vs. pre-frail/robust; odds ratio 2.38, 95% CI 1.01, 5.67) and with having reduced quality of life (coefficient -2.18, 95% CI -3.92, -0.44). Our findings suggest that HIV is associated with increased biological age and that CH may be used as a biomarker for adverse geriatric outcomes.