A comprehensive analysis of the epidemiological and genomic characteristics of global Serratia Marcescens

作者：Wenqin Chen, Zheqian Li, Jie Zheng, Danwei Wang, Shuo Gao, Wanqing Zhou, Han Shen, Yan Zhang, Xiaoli Cao · 发表于：Journal of Global Antimicrobial Resistance · 年份：2024 · DOI：10.1016/j.jgar.2024.11.013 · 被引用次数：7 · 研究领域：Antibiotic Resistance in Bacteria、Antimicrobial Resistance in Staphylococcus、Bacterial Identification and Susceptibility Testing

• Global analysis of 1,464 Serratia marcescens genomes from 33 countries. • Human-derived genomes dominated (73.5%), mainly from blood (44.8%) and sputum (19.3%). • Identified 11 key antimicrobial resistance genes, including novel armA, rmtC , and fosA7.2 . • Predominant carbapenemase genes: blaSME, blaKPC , and blaNDM-1 , with no co-existence in single strains. • Common sequence types: ST366, ST367, ST365, and ST423, with high diversity in the UK. • Phylogenetic analysis revealed genetic diversity and distinct evolutionary lineages. • Highlights the role of horizontal gene transfer in resistance, urging prudent antibiotic use. Serratia marcescens outbreaks present significant challenges in clinical treatment, necessitating a deeper understanding of its epidemiological and genomic traits. To analyze the epidemiological and genomic characteristics of S. marcescen s at a global scale. High-quality genomes of S. marcescens were retrieved from NCBI and annotated using Prodigal. Antibiotic resistance genes (ARGs) were identified via Blastn, sequence types (STs) were determined with a proprietary tool, and phylogenetic analysis was conducted to explore evolutionary relationships. The study analyzed genomes from 33 countries, with major contributions from the USA (27.8%), UK (15.3%), Italy (14.7%), and Japan (10.7%). Human clinical samples accounted for 73.5% of the isolates, primarily from blood (44.8%) and sputum (19.3%). Eleven ARGs were identified, with sde being the most preval...