Respiratory Benefits of Multisetting Air Purification in Children

作者：Jian Lei, Qinghua Sun, Renjie Chen, Yixiang Zhu, Lu Zhou, Xiaowei Xue, Jianlong Fang, Yanjun Du, Yanwen Wang, Tiantian Li, Haidong Kan · 发表于：Archives of Pediatrics and Adolescent Medicine · 年份：2024 · DOI：10.1001/jamapediatrics.2024.5049 · 被引用次数：11 · 研究领域：Indoor Air Quality and Microbial Exposure、Air Quality and Health Impacts、Asthma and respiratory diseases

Importance: Particulate matter exposure has been linked to impaired respiratory health in children, but the respiratory benefits of air purification have not been fully elucidated. Objectives: To assess the respiratory health outcomes among children exposed to multisetting air purification vs sham purification. Design, Setting, and Participants: This cluster randomized, double-blind, crossover trial was conducted among healthy school-aged children (10-12 years) in China from April to December 2021. Data were analyzed from December 2021 to July 2024. Interventions: A multisetting (both in classrooms and bedrooms) air purification intervention compared with sham purification in a 2-stage intervention with more than 2 months (76 days) for each period and a washout period (88 days) to estimate the respiratory benefits of air purification. Main Outcomes and Measures: The primary outcomes were pulmonary function, airway inflammation markers, and metabolites in exhaled breath condensate (EBC) before and after the air purification intervention. Linear mixed-effects models were used to estimate the respiratory benefits of children related to air purification. Differential metabolites in EBC were identified using metabolomics analysis to explore their possible mediation roles. Results: A total of 79 children (38 male [48%]; mean [SD] age, 10.3 [0.5] years) were included in the statistical analyses. During the study period, the mean (SD) concentration of outdoor fine particulate matter ...