BCPT perspectives on studies involving natural products, traditional Chinese medicine and systems pharmacology

作者：Pernille Tveden‐Nyborg, Baoxue Yang, Ulf Simonsen, Jens Lykkesfeldt · 发表于：Basic & Clinical Pharmacology & Toxicology · 年份：2024 · DOI：10.1111/bcpt.14109 · 被引用次数：35 · 研究领域：Microbial Natural Products and Biosynthesis、Metabolomics and Mass Spectrometry Studies、Computational Drug Discovery Methods

Natural products constitute a vast source of bioactive compounds with the potential of providing valuable insight for future medicines. However, from a pharmacological perspective, natural product studies are also often accompanied by serious limitations due to, for example, the complex nature of biological extracts, the challenge of reproducibly characterizing the extract and providing an exhaustive list of constituents and, consequently, the difficulties in linking the observed pharmacological effects to specific chemical entities. The present paper discusses the major challenges of studies with natural products and provides a guideline to be followed by authors submitting research findings involving data from natural products, and their derivatives, to Basic & Clinical Pharmacology & Toxicology.