Progress in Biomaterials-Enhanced Vascularization by Modulating Physical Properties

作者：Hao Li, Dayan Li, Xue Wang, Xue Wang, Ziyuan Zeng, Sara Pahlavan, Wei Zhang, Xi Wang, Xi Wang, Kai Wang · 发表于：ACS Biomaterials Science & Engineering · 年份：2024 · DOI：10.1021/acsbiomaterials.4c01106 · 被引用次数：10 · 研究领域：Electrospun Nanofibers in Biomedical Applications、Bone Tissue Engineering Materials、Tissue Engineering and Regenerative Medicine

Sufficient vascular system and adequate blood perfusion is crucial for ensuring nutrient and oxygen supply within biomaterials. Actively exploring the optimal physical properties of biomaterials in various application scenarios has provided clues for enhancing vascularization within materials, leading to improved outcomes in tissue engineering and clinical translation. Here we focus on reviewing the physical properties of biomaterials, including pore structure, surface topography, and stiffness, and their effects on promoting vascularization. This angiogenic capability has the potential to provide better standardized research models and personalized treatment strategies for bone regeneration, wound healing, islet transplantation and cardiac repair.