Diabetes remission in newly diagnosed type 2 diabetes mellitus through short‐term continuous subcutaneous insulin infusion intensive therapy combined with low‐carbohydrate diet treatment

作者：Xuemei Huang, Jiajin Jiang, Li Liu, Yuanyuan Lin, Feng Zhang, Xiaoshan Ling, Haitao Wei, Guangjing Huang, Jiasen Ye, Cen Huang, Jianli Huang, Wenfu Tao, Xinyu Zou · 发表于：Journal of Diabetes Investigation · 年份：2024 · DOI：10.1111/jdi.14371 · 被引用次数：5 · 研究领域：Bariatric Surgery and Outcomes、Diet and metabolism studies、Hyperglycemia and glycemic control in critically ill and hospitalized patients

AIM/INTRODUCTION: To evaluate the therapeutic efficacy short-term continuous subcutaneous insulin infusion (CSII) intensive therapy combined with a low-carbohydrate diet (LCD) for diabetes remission in patients with newly diagnosed type 2 diabetes mellitus. MATERIALS AND METHODS: This study included patients newly diagnosed with type 2 diabetes mellitus, who were randomly divided into two groups: conventional (conventional CSII + traditional lifestyle guidance); and intensive (intensive CSII + LCD lifestyle guidance). CSII was used for blood glucose control, with continuous glucose monitoring (CGM) used to monitor blood glucose levels. The primary outcome measure was hemoglobin A1c (HbA1c) level; secondary outcomes included body weight, body mass index (BMI), waist circumference, glycemic control, and biochemical indices. RESULTS: The time in range (TIR) in the intensive treatment group was greater than that in the conventional treatment group (P < 0.05). There was no significant difference in the incidence of hypoglycemia between the two groups (P > 0.05). Compared with the conventional treatment group, diabetes remission rates were significantly greater in the intensive treatment group (P < 0.05). In the intensive treatment group, fasting plasma glucose (FPG), HbA1c, Homeostasis Model assessment of Insulin Resistance (HOMA-IR), triglycerides (TG), low-density lipoprotein cholesterol (LDL-c), and changes in body weight, BMI, visceral fat area (VFA), and subcutaneous fat area...