Role of Oxidative Stress in Blood–Brain Barrier Disruption and Neurodegenerative Diseases

作者：Sehwan Kim, Sehwan Kim, Un Ju Jung, Sang Ryong Kim, Sang Ryong Kim · 发表于：Antioxidants · 年份：2024 · DOI：10.3390/antiox13121462 · 被引用次数：145 · 研究领域：Alzheimer's disease research and treatments、Trace Elements in Health、Parkinson's Disease Mechanisms and Treatments

Upregulation of reactive oxygen species (ROS) levels is a principal feature observed in the brains of neurodegenerative diseases such as Parkinson's disease (PD) and Alzheimer's disease (AD). In these diseases, oxidative stress can disrupt the blood-brain barrier (BBB). This disruption allows neurotoxic plasma components, blood cells, and pathogens to enter the brain, leading to increased ROS production, mitochondrial dysfunction, and inflammation. Collectively, these factors result in protein modification, lipid peroxidation, DNA damage, and, ultimately, neural cell damage. In this review article, we present the mechanisms by which oxidative damage leads to BBB breakdown in brain diseases. Additionally, we summarize potential therapeutic approaches aimed at reducing oxidative damage that contributes to BBB disruption in neurodegenerative diseases.