Pulsed Field Ablation of Paroxysmal Supraventricular Tachycardia: A Prospective Multicenter Single-Arm Study in China

作者：Fanghui Li, Aobo Gong, Hongde Hu, Kaijun Cui, Qing Yang, Xiaobo Pu, Shi Chen, Jian Jiang, Hua Fu, Hanxiong Liu, Yuehui Yin, Qiangsun Zheng, Maoqin Shu, Chun Gui, Jian Xu, Pingzhen Yang, Zhiyu Ling, Hong-Zhi Wang, Tingting Yang, Rongzheng Yue, Jinnian Gao, Xiaolin Zhu, Tiancai Shi, Wentao Li, Xianjin Hu, Yao Tong, Qing Zhang, Rui Zeng · 发表于：Circulation Arrhythmia and Electrophysiology · 年份：2024 · DOI：10.1161/circep.124.013206 · 被引用次数：9 · 研究领域：Cardiac Arrhythmias and Treatments、Atrial Fibrillation Management and Outcomes、Vascular anomalies and interventions

BACKGROUND: Pulsed field ablation (PFA) has gained attention in cardiac electrophysiology, but data on its application to paroxysmal supraventricular tachycardia are limited. This study aimed to assess the feasibility and safety of PFA and its combination with radiofrequency ablation for treating paroxysmal supraventricular tachycardia. METHODS: A prospective, multicenter, single-arm study was conducted across 8 centers in China. Patients with atrioventricular nodal reentrant tachycardia, atrioventricular reentrant tachycardia, or Wolff-Parkinson-White syndrome underwent ablation using a focal point dual-mode PFA/radiofrequency ablation catheter. PFA was used to achieve acute ablation success, with consolidation using PFA for atrioventricular nodal reentrant tachycardia or near-His accessory pathways and radiofrequency ablation for far-His accessory pathways. Primary and secondary end points were acute ablation success and 180-day follow-up success, respectively. RESULTS: A total of 158 patients (77 with atrioventricular nodal reentrant tachycardia, 63 with atrioventricular reentrant tachycardia, 16 with Wolff-Parkinson-White, and 2 with both atrioventricular nodal reentrant tachycardia and atrioventricular reentrant tachycardia) completed the trial. Acute ablation was successful in 157 patients (99.37%). The skin-to-skin procedure time was 89.9±35.5 min. The median number of PFA discharges was 12 (8-19) with a median effective PFA discharge time of 4.6 (3.2-6.4) ms. Five pat...