Effects of pharmacogenomics-guided treatment on medication adherence and the antidepressant switching rate in major depressive disorder

作者：Chaoli Chen, Yang Lun, Jing Yu, Xiaochuan Zhao, Shijie Su, Mengqiang Zhao, Yuhang Yan, Jiaqi Wang, Jiaqi Wang, Ran Fu, Feng‐Rong An, Liguang Duan, Leting Yan, Ruxing Li, Jinxiao Li, Ziyu Liu, Xiaoying Geng, Jincheng Wang, Jincheng Wang, Yuanyuan Zhao, Chunhua Zhou · 发表于：Frontiers in Pharmacology · 年份：2024 · DOI：10.3389/fphar.2024.1501381 · 被引用次数：5 · 研究领域：Treatment of Major Depression、Tryptophan and brain disorders、Pharmacogenetics and Drug Metabolism

Background In the treatment of depression, medication plays a crucial role. However, insufficient patient adherence to medication often results in unsatisfactory treatment outcomes, increasing both the recurrence and rehospitalization rates of depression, and consequently imposing a greater economic burden on the healthcare system. Objectives Our objective was to examine the impact of pharmacogenomic testing on medication adherence and antidepressant switching rates among individuals diagnosed with depression. Methods This retrospective cohort study encompassed patients diagnosed with depression who were admitted to the First Hospital of Hebei Medical University between April 2022 and September 2023. Patients were categorized into a pharmacogenomics-guided treatment (PGxT) group and a treatment as usual (TAU) group based on whether pharmacogenetic testing was conducted. The primary outcome measures included the proportion of patients exhibiting medication adherence greater than 80% at three and 6 months post-discharge, as well as the proportion of patients experiencing changes in their prescribed medication types. Results A total of 310 patients in the PGxT group and TAU group were obtained through propensity score matching. Among the 620 patients in both groups, 57.42% demonstrated good adherence (≥80%) at 3 months; this percentage dropped to 31.45% at 6 months. At 3 months of observation, the percentages of patients demonstrating good adherence were significantly different ...