Reduced cofilin activity as a mechanism contributing to endothelial cell stiffening in type 2 diabetes

作者：Gavin Power, Olubodun Michael Lateef, Francisco I. Ramirez‐Perez, Yoskaly Lazo‐Fernandez, Marc A. Augenreich, Larissa Ferreira‐Santos, Rogério N. Soares, Juan D. Gonzalez-Vallejo, Mariana Morales‐Quinones, Charles E. Norton, Camila Manrique‐Acevedo, Luis A. Martinez‐Lemus, Jaume Padilla · 发表于：American Journal of Physiology-Heart and Circulatory Physiology · 年份：2024 · DOI：10.1152/ajpheart.00667.2024 · 被引用次数：8 · 研究领域：Cellular Mechanics and Interactions、Cell Adhesion Molecules Research、Blood properties and coagulation

Cell stiffening is an emerging contributor to endothelial dysfunction, a classic feature of type 2 diabetes (T2D). However, the mechanisms underlying endothelial stiffening remain largely unknown. This work provides evidence that oxidative stress-induced inactivation of cofilin, a key F-actin severing protein, may be implicated in increasing endothelial F-actin and cell stiffness in T2D.