Inflammation-based scores predict chronic kidney disease progression in patients with chronic kidney disease and chronic heart failure

作者：Lu Cai, Licong Su, Ying Hu, Endi Cai, Hongxia Xu, Bi‐Cheng Liu, Jianping Weng, Chunbo Chen, Jialu Liu, Qiong Yang, Hua Li, Yaozhong Kong, Guisen Li, Qijun Wan, Yan Zha, Gang Xu, Yongjun Shi, Yilun Zhou, Guobin Su, Ying Tang, Mengchun Gong · 发表于：Renal Failure · 年份：2024 · DOI：10.1080/0886022x.2024.2432541 · 被引用次数：7 · 研究领域：Inflammatory Biomarkers in Disease Prognosis、Dialysis and Renal Disease Management、Parathyroid Disorders and Treatments

BACKGROUND: Inflammation is associated with adverse outcomes of chronic kidney disease (CKD) or chronic heart failure (CHF), but few large data exist. We aimed to explore the clinical associations, and prognostic consequences of inflammation-based scores in patients with CKD and CHF. METHODS: This work was a retrospective cohort study. Glasgow Prognostic Score (GPS), modified Glasgow Prognostic Score (mGPS), Prognostic Nutritional Index (PNI) and Prognostic Index (PI), were used to explore its relationship with CKD progression in patients with CKD stage 1-3b and CHF from the China Renal Data System (CRDS). The composite end point of this study was CKD progression which was defined as eGFR reduction of 40% or progression to end stage renal disease (ESRD). RESULTS: < 0.001]. PNI showed acceptable prognostic value (C-index = 0.757, 95% CI 0.734-0.78) compared to GPS, mGPS and PI. In subgroup analysis, PNI was consistently related to CKD progression in patients with or without hypertension, DM, MI, VDH and CVD (P for interaction > 0.05). CONCLUSIONS: Inflammation-based scores, especially PNI may be a useful clinical biomarker for CKD progression in CKD with CHF patients.