Evaluating a new obesity indicator for stroke risk prediction: comparative cohort analysis in rural settings of two nations

作者：Feifei Yao, Jing Cui, Yuncheng Shen, Yuting Jiang, Yuanyuan Li, Xiaona Liu, Hongqi Feng, Zhe Jiao, Chang Liu, Fulan Hu, Wei Zhang, Dianjun Sun · 发表于：BMC Public Health · 年份：2024 · DOI：10.1186/s12889-024-20631-5 · 被引用次数：29 · 研究领域：Chronic Disease Management Strategies、Acute Ischemic Stroke Management、Diabetes, Cardiovascular Risks, and Lipoproteins

While the TyG index has been studied in relation to stroke risk, there is a lack of research integrating fat distribution indicators like Body Roundness Index (BRI) and Fat Mass Index (FMI). Additionally, comparative studies across multiple regions are scarce. This study investigates the association between obesity-related parameters and stroke incidence, examining the mediation effects of multimorbidity, using data from rural areas in China and the United Kingdom. This cohort study included 60,685 participants (6,980 from China and 53,705 from UK). The obesity-related parameters were calculated using established formulas. The TyG index was determined as ln [TG (mg/dL) × GLU (mg/dL) / 2]. Additionally, composite indices were created by multiplying the TyG index by BMI, WC, FMI, and RBI to assess obesity-related risks. Cox regression analyses were employed on the relationship between Triglyceride Glucose index related parameters and stroke risk. Multiple mediation analysis was applied to assess the contributions of multimorbidity to obesity indicators in stroke occurrence. After excluding those who developed stroke within two years of enrollment, the Chinese cohort (6,638 subjects, median follow-up 4.33 years) had 237 ischemic and 21 hemorrhagic strokes. The UK cohort (53,631 subjects, median follow-up 13.85 years) had 742 ischemic and 316 hemorrhagic strokes. Chinese residents had lower BMI but higher visceral obesity (BRI), higher prevalence of multimorbidity, and higher str...