Taurine Supplementation Alleviates Blood Pressure via Gut–Brain Communication in Spontaneously Hypertensive Rats

作者：Qing Su, Xiong-Feng Pan, Hong‐Bao Li, Ling-Xiao Xiong, Juan Bai, Xiaomin Wang, Xiaoying Qu, Nana Zhang, Guo-Quan Zou, Yang Shen, Lu Li, Li-Li Huang, Huan Zhang, Menglu Xu · 发表于：Biomedicines · 年份：2024 · DOI：10.3390/biomedicines12122711 · 被引用次数：7 · 研究领域：Aldose Reductase and Taurine、Peroxisome Proliferator-Activated Receptors、Nitric Oxide and Endothelin Effects

OBJECTS: Taurine exhibits protective effects in the context of cardiovascular pathophysiology. A range of evidence suggests that hypertension activates inflammatory responses and oxidative stress in the paraventricular nucleus (PVN), elevating the arterial tone and sympathetic activity, while it induces gut-brain axis dysfunction in the context of hypertension. However, the mechanism underlying taurine's anti-hypertensive effects via the gut-brain axis remains unclear. METHOD: Male spontaneously hypertensive rats (SHRs) were administered 3% taurine in their drinking water for eight weeks, with their arterial pressure measured weekly. Molecular techniques were employed to investigate taurine's effects on the hypertensive gut and PVN. Additionally, 16S rRNA gene sequencing was used to analyze the gut microbiota composition, and untargeted metabolomics was applied to assess the fecal metabolites following taurine supplementation. RESULTS: Taurine supplementation not only reduced the blood pressure, sympathetic activity, and inflammatory and oxidative stress in the PVN but also improved the cardiac pathology and microbiota composition while alleviating gut inflammation in hypertensive rats. The untargeted metabolite analysis indicated that the primary effect of the taurine intervention in SHRs was exerted on tryptophan metabolism. The levels of serum metabolites such as kynurenine, L-tryptophan, serotonin (5-HT), and 5-hydroxyindole-3-acetic acid (5-HIAA) were altered in hyperten...