Investigating timing of BOLD fMRI responses in individual cortical vessels to short and long stimulus durations

作者：Divya Varadarajan, Sebastien Proulx, Paul Wighton, Zhangxuan Hu, Jingyuan Chen, Saskia Bollmann, Avery Berman, Jon̈athan R. Polimeni · 发表于：Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition · 年份：2024 · DOI：10.58530/2024/0536 · 被引用次数：1 · 研究领域：Functional Brain Connectivity Studies、Advanced MRI Techniques and Applications、Neural dynamics and brain function

Motivation: Typical fMRI data observes hemodynamics from multiple vascular compartments in each voxel, however understanding the link between neuronal and vascular dynamics will require vessel-specific measurements. Goal(s): To investigate the timing and amplitude of hemodynamic responses within individual arteries and veins of the human cortex and assess how they change with stimulus duration. Approach: We applied single-vessel fMRI with multiple echoes to separate inflow and BOLD components, and distinguished intravascular and extravascular dynamics in and around arteries and veins. Results: We observed faster dynamics in arteries, and a post-stimulus undershoot in all vessels, potentially providing new insights into hemodynamics in the human brainImpact: Knowledge about hemodynamics within individual vascular compartment is provided by invasive microscopy in small-animal models, and less is known about hemodynamics in humans. Here we present vessel-specific measurements of hemodynamics in humans and reveal unexpected features in the fMRI response.