Association between folate deficiency and hypertension: evidence from an observational and Mendelian randomization study

作者：Yanyu Zhang, Darui Gao, Jie Liang, Mengmeng Ji, Wenya Zhang, Yang Pan, Fanfan Zheng, Wuxiang Xie · 发表于：European Journal of Preventive Cardiology · 年份：2024 · DOI：10.1093/eurjpc/zwae386 · 被引用次数：6 · 研究领域：Folate and B Vitamins Research、Genetic Associations and Epidemiology、Connective tissue disorders research

AIMS: Although folate intake might affect hypertension risk, evidence about the risk of hypertension according to an individual's folate deficiency status is scarce. Therefore, we aimed to investigate the relationship between folate deficiency and hypertension, and their causal associations. METHODS AND RESULTS: A cross-sectional and prospective cohort study was performed in the UK Biobank (UKB) to investigate the associations between folate deficiency and hypertension prevalence and incidence, using logistic regression and Cox proportional hazard regression, respectively. Subsequently, we conducted one-sample Mendelian randomization (MR) with individual-level data from the UKB to further validate their causal associations. Finally, two-sample MR analyses were applied using summary-level data to further assess the causal relationships of serum folate with blood pressure (BP) and hypertension. In a total of up to 219 089 participants free of hypertension at enrolment, 17 670 participants developed hypertension after a median of 12.8 years of follow-up. Compared with participants without folate deficiency, those with folate deficiency had a higher risk of hypertension (HR = 1.42, 95% CI = 1.24-1.63). One-sample MR analysis in the UKB provided supportive evidence for a causal effect of folate deficiency on hypertension risk (odds ratio for the highest quantile = 1.07, 95% CI = 1.04-1.10, Ptrend < 0.001). Furthermore, two-sample MR also supported a protective effect of higher lev...