Dual activation of GCGR/GLP1R signaling ameliorates intestinal fibrosis via metabolic regulation of histone H3K9 lactylation in epithelial cells

作者：Han Liu, Yujie Hong, Hui Chen, Xianggui Wang, Jiale Dong, Xiaoqian Li, Zihan Shi, Qian Zhao, Longyuan Zhou, Jiaxin Wang, Qiuling Zeng, Qinglin Tang, Qi Liu, Florian Rieder, Baili Chen, Minhu Chen, Rui Wang, Yao Zhang, Ren Mao, Xianxing Jiang · 发表于：Acta Pharmaceutica Sinica B · 年份：2024 · DOI：10.1016/j.apsb.2024.11.017 · 被引用次数：20 · 研究领域：Digestive system and related health、Pancreatic and Hepatic Oncology Research、Epigenetics and DNA Methylation

histone lactylation. Simultaneously activating GCGR/GLP1R with the novel dual agonist peptide 1907B holds promise as a treatment strategy for alleviating intestinal fibrosis.