Estimated Brain Age in Healthy Aging and Across Multiple Neurological Disorders

作者：Li Chai, Jun Sun, Zhizheng Zhuo, Wei Ren, Xiaolu Xu, Yunyun Duan, De‐Cai Tian, Yutong Bai, Ningnannan Zhang, Haiqing Li, Yuxin Li, Yongmei Li, Fuqing Zhou, Jun Xu, James H. Cole, Frederik Barkhof, Jianguo Zhang, Huaguang Zheng, Yaou Liu · 发表于：Journal of Magnetic Resonance Imaging · 年份：2024 · DOI：10.1002/jmri.29667 · 被引用次数：12 · 研究领域：Multiple Sclerosis Research Studies、Dementia and Cognitive Impairment Research、Advanced Neuroimaging Techniques and Applications

BACKGROUND: The brain aging in the general population and patients with neurological disorders is not well understood. PURPOSE: To characterize brain aging in the above conditions and its clinical relevance. STUDY TYPE: Retrospective. POPULATION: A total of 2913 healthy controls (HC), with 1395 females; 331 multiple sclerosis (MS); 189 neuromyelitis optica spectrum disorder (NMOSD); 239 Alzheimer's disease (AD); 244 Parkinson's disease (PD); and 338 cerebral small vessel disease (cSVD). FIELD STRENGTH/SEQUENCE: 3.0 T/Three-dimensional (3D) T1-weighted images. ASSESSMENT: The brain age was estimated by our previously developed model, using a 3D convolutional neural network trained on 9794 3D T1-weighted images of healthy individuals. Brain age gap (BAG), the difference between chronological age and estimated brain age, was calculated to represent accelerated and resilient brain conditions. We compared MRI metrics between individuals with accelerated (BAG ≥ 5 years) and resilient brain age (BAG ≤ -5 years) in HC, and correlated BAG with MRI metrics, and cognitive and physical measures across neurological disorders. STATISTICAL TESTS: Student's t test, Wilcoxon test, chi-square test or Fisher's exact test, and correlation analysis. P < 0.05 was considered statistically significant. RESULTS: In HC, individuals with accelerated brain age exhibited significantly higher white matter hyperintensity (WMH) and lower regional brain volumes than those with resilient brain age. BAG was si...