The association between ozone exposure and blood pressure in a general Chinese middle-aged and older population: a large-scale repeated-measurement study

作者：Chen Tang, Yiqin Zhang, Jingping Yi, Zhonghua Lu, Xianfa Xuan, Hanxiang Jiang, Dongbei Guo, Hanyu Xiang, Ting Wu, Jianhua Yan, Siyu Zhang, Yuxin Wang, Jie Zhang · 发表于：BMC Medicine · 年份：2024 · DOI：10.1186/s12916-024-03783-4 · 被引用次数：6 · 研究领域：Air Quality and Health Impacts、Climate Change and Health Impacts、Health, Environment, Cognitive Aging

The relationship between ozone (O 3 ) exposure and blood pressure (BP) remains inconclusive. Given the scarcity of Chinese epidemiological data, more research on this association is of paramount importance, particularly among middle-aged and older Chinese populations. This study involved 10,875 participants (median age: 60.0 years) in Xiamen, China, from 2013 to 2019, with 34,939 repeated BP measurements. Air pollutant exposure data, including O 3 , particulate matter, nitrogen dioxide, sulfur dioxide, and carbon monoxide were derived from China High Air Pollutants and High-resolution Air Quality Reanalysis datasets using a k-nearest neighbor algorithm. The relationship between mixed air pollutant exposure and BP was evaluated using Bayesian kernel machine regression model. The effects of daily-specific O 3 exposure on BP were assessed by distributed lag models integrated into a linear mixed-effects framework. The mediating role of total cholesterol (TC), serum total bilirubin (STB), triglyceride (TG), and low-density lipoprotein (LDL) were examined using multilevel mediation analysis with a fully adjusted model. Mixed air pollutant exposure was positively correlated with BP, with O 3 being a predominant contributor exhibiting an inverse effect. O 3 exposure had immediate effects on pulse pressure (PP), while systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) showed delayed responses, with 3-, 14-, and 8-day lags, respectively. Dur...