Characteristics of cytokines/chemokines associated with disease severity and adverse prognosis in COVID-19 patients

作者：Jianghao Cheng, Haozhen Wang, Chaodan Li, Jianhua Yu, Mingli Zhu · 发表于：Frontiers in Immunology · 年份：2024 · DOI：10.3389/fimmu.2024.1464545 · 被引用次数：8 · 研究领域：COVID-19 Clinical Research Studies、Chemokine receptors and signaling、Long-Term Effects of COVID-19

Background: Cytokines and chemokines as crucial participants in innate immune response play significant roles during SARS-CoV-2 infection, yet excessive immune response exacerbates the severity of COVID-19. Purpose: This study aims to investigate the involvement of which cytokines/chemokines in the cytokine storm of COVID-19, as well as the changes in cytokine/chemokine levels during the course of COVID-19, simultaneously exploring the diagnostic and prognostic value of the relevant cytokines/chemokines for COVID-19. Methods: Flow cytometry was employed to detect the levels of cytokines and chemokines in the serum of 50 COVID-19 patients. Results: Compared with severe COVID-19 patients, the levels of cytokines IL-6, IL-8, IL-10, sCD25, and chemokines IP-10 and MIG in the peripheral blood of non-severe patients were significantly reduced, while only IL-6, IL-10, and IP-10 levels were significantly decreased compared to non-survivors of COVID-19. Meanwhile, serum concentrations of IP-10, MCP-1, sTREM-1, IL-10, and the neutrophil-to-lymphocyte ratio (NLR) in peripheral blood could distinguish between COVID-19 survivors and non-survivors and were significantly associated with mortality. Among them, the concentration of IP-10 was shown to be the most powerful indicator for predicting adverse outcomes in COVID-19 patients (AUC: 0.715); however, its combined detection with the conventional inflammatory marker NLR did not improve the predictive value for adverse outcomes in COVID-19 ...