Prevalence of mixed neuropathologies in age‐related neurodegenerative diseases: A community‐based autopsy study in China

作者：Xiaoxi Wang, Keqing Zhu, Wei Wu, Dan Zhou, Hui Lu, Juan Du, Li Cai, Xiao‐Xin Yan, Wensheng Li, Xiaojing Qian, Xue Wang, Chao Ma, Yuting Hu, Chen Tian, Bing Sun, Zheng Fang, Juanli Wu, Peiran Jiang, Jianxin Liu, Cui-Yun Liu, Jiayao Fan, Huixian Cui, Yi Shen, Shumin Duan, Ai‐Min Bao, Ying Yang, Wenying Qiu, Jing Zhang · 发表于：Alzheimer s & Dementia · 年份：2024 · DOI：10.1002/alz.14369 · 被引用次数：20 · 研究领域：Dementia and Cognitive Impairment Research、Alzheimer's disease research and treatments、Parkinson's Disease Mechanisms and Treatments

INTRODUCTION: Despite extensive studies on mixed neuropathologies, data from China are limited. This study aims to fill this gap by analyzing brain samples from Chinese brain banks. METHODS: A total of 1142 brains from six Chinese brain banks were examined using standardized methods. Independent pathologists conducted evaluations with stringent quality control. Prevalence and correlations of neurological disorders were analyzed. RESULTS: Significant proportions of brains displayed primary age-related tauopathy (PART, 35%), limbic-predominant age-related TDP-43 encephalopathy (LATE, 46%), and aging-related tau astrogliopathy (ARTAG, 12%). Alzheimer's disease neuropathological change (ADNC, 48%), Lewy body disease (LBD, 13%), and cerebrovascular disease (CVD, 63%) were also prevalent, often co-occurring with regional variations. CVD emerged as the potential most early contributor to neuropathological changes. DISCUSSION: This analysis highlights the prevalence of PART, LATE, ARTAG, ADNC, LBD, and CVD, with regional differences. The findings suggest CVD may be the earliest contributing factor, potentially preceding other neuropathologies. Highlights The prevalence of primary age-related tauopathy (PART), limbic-predominant age-related TDP-43 encephalopathy (LATE), aging-related tau astrogliopathy (ARTAG), Alzheimer's disease neuropathologic change, Lewy body disease, and cerebrovascular disease (CVD) in China, increasing with age, is comparable to other countries. Significant re...