Association between low-density lipoprotein cholesterol levels and all-cause mortality in patients with coronary artery disease: a real-world analysis using data from an international network

作者：Thiago Luis Scudeler, Leandro Menezes Alves da Costa, Rafael Amorim Belo Nunes, Rafael Otto Schneidewind, Thiago Midlej Brito, Daniel Castanho Genta Pereira, Roger Pereira de Oliveira, Genara Santana, Hélio José Castello, Marcelo José de Carvalho Cantarelli, Álvaro Avezum · 发表于：Scientific Reports · 年份：2024 · DOI：10.1038/s41598-024-80578-w · 被引用次数：15 · 研究领域：Lipoproteins and Cardiovascular Health、Diabetes, Cardiovascular Risks, and Lipoproteins、Health Systems, Economic Evaluations, Quality of Life

The current cholesterol guidelines recommend maintaining low levels of low-density lipoprotein cholesterol (LDL-C) in patients with coronary artery disease (CAD). However, recent studies have suggested that both very low and very high LDL-C levels may be associated with increased mortality in the general population. We utilized data from TriNetX, a global health research network, to investigate the association between LDL-C levels and all-cause mortality in patients with CAD. CAD patients were identified using the International Classification of Diseases, Tenth Revision (ICD-10) diagnosis code and stratified into six LDL-C categories: <50 mg/dL (cohort 1), 50-69.9 mg/dL (cohort 2), 70-99.9 mg/dL (cohort 3), 100-129.9 mg/dL (cohort 4), 130-159.9 mg/dL (cohort 5), and ≥ 160 mg/dL (cohort 6). Mortality data were obtained by linking patient records to death registries spanning the 15 years prior to the analysis. Weighted Cox proportional hazards regression models were employed to estimate hazard ratios (HRs) for mortality outcomes along with their 95% confidence intervals (CIs). A total of 2,145,732 individuals with CAD (mean age 72 years, SD 13; mean LDL-C 87.7 mg/dL, SD 37.7) were included in the analysis. Over a 15-year follow-up period, 191,779 deaths (8.9%) were recorded. After propensity score matching, patients with LDL-C < 50 mg/dL (37.05% vs. 33.11%, HR 1.144, 95% CI 1.125-1.164, p < 0.0001), LDL-C 130-159.9 mg/dL (26.47% vs. 25.71%, HR 1.032, 95% CI 1.007-1.059, p = 0.0...