Influence of Inflammation on Red Blood Cell Lifespan in Peritoneal Dialysis Patients

作者：Huiping Zhao, Yuchao Zhao, Bei Wu, Li Bai, Lixia Lu, Zuo Li · 发表于：Journal of Clinical Medicine · 年份：2024 · DOI：10.3390/jcm13237104 · 被引用次数：2 · 研究领域：Dialysis and Renal Disease Management、Blood properties and coagulation、Erythrocyte Function and Pathophysiology

Background and hypothesis: Renal anemia is linked to a decreased lifespan of red blood cells. The factors influencing red blood cell lifespan (RBCLS) in peritoneal dialysis patients, particularly the connection between inflammation and RBCLS, are still not well understood. This cross-sectional study was conducted to investigate these relationships. Methods: Patients who had been undergoing peritoneal dialysis for more than 3 months were selected for this study. The carbon monoxide exhalation method was used to detect the life span of red blood cells. The patients were then divided into two groups based on whether the RBCLS was shorter than 75 days. General information, anemia-related indicators, and other laboratory indicators along with their treatment were compared between the two groups. The different indicators were then included in a logistic regression analysis to identify independent risk factors that influence the shortening of RBCLS. Results: A cohort of 59 peritoneal dialysis patients was examined, revealing a median RBCLS of 88 days. Of these patients, 39 exhibited a normal RBCLS, while 20 had a shortened lifespan. A comparison of the two groups indicated that patients with a shorter RBCLS exhibited lower levels of PD vintage (29.5 vs. 56.0, p = 0.031), albumin (34.62 ± 3.01 vs. 37.41 ± 3.60, p = 0.004), cholesterol (4.02 ± 0.54 vs. 4.55 ± 1.21, p = 0.026), and low-density cholesterol (2.19 ± 0.43 vs. 2.75 ± 0.87, p = 0.002), and a higher neutrophil-to-lymphocyte r...