Identification and validation of serum MUC17 as a non‐invasive early warning biomarker for screening of gastric intraepithelial neoplasia

作者：Bingxue Yang, Xiao‐Li Xie, Xiaoxu Jin, Xiuhong Huang, Yujian He, Kaige Yin, Chenguang Ji, Li Liu, Zhijie Feng · 发表于：Translational Oncology · 年份：2024 · DOI：10.1016/j.tranon.2024.102207 · 被引用次数：5 · 研究领域：Helicobacter pylori-related gastroenterology studies、Gastric Cancer Management and Outcomes、Esophageal Cancer Research and Treatment

• The expression of MUC17 progressively increases during the transition from low-grade intraepithelial neoplasia to advanced gastric cancer. • MUC17 has potential utility as a non-invasive serological marker for gastric intraepithelial neoplasia, facilitating the screening of patients with malignant tendencies prior to gastroscopy. • MUC17 is organ-specific to gastric cancer and is not elevated in many other types of cancer. • MUC17 can be used in the differential diagnosis of other endoscopic gastric mass. The early diagnosis and treatment of Gastric Intraepithelial Neoplasia (GIN) are pivotal for improving the survival rates of patients with gastric cancer (GC). Regrettably, reliable noninvasive biomarkers for GIN screening are currently lacking. mRNA data from the GEO database, pan-cancer data from the TCGA database, and a gene list of exocrine proteins were subjected to integrated analysis to identify a noninvasive biomarker for GIN. The scRNA-seq data analysis, IHC and Elisa were employed to validate the expression of the biomarker in the serum and tissues of clinical patients across different pathological stages. MUC17 has been identified as a non-invasive diagnostic marker for GIN. It is upregulated in GIN prior to the onset of gastric carcinogenesis and downregulated in other tumors, with high GC specificity. The area under the curve values of serum MUC17 for differentiating chronic gastritis (CG) from low-grade intraepithelial neoplasia (LGIN), high-grade intraepithe...