Water-enabled α -C(sp 3 )–H amination via [1,6]-hydride transfer: green access to diazepino[6,5,4- cd ]indoles

作者：Yao‐Bin Shen, Xiao-Lin Wang, Qian-Hao Zhuang, Xiao‐De An, Bin Qiu, Houchen Wang, Tiesheng Shi, Jian Xiao · 发表于：Organic Chemistry Frontiers · 年份：2024 · DOI：10.1039/d4qo01761g · 被引用次数：24 · 研究领域：Synthesis and Catalytic Reactions、Catalytic C–H Functionalization Methods、Asymmetric Hydrogenation and Catalysis

Water-enabled α -C(sp 3 )–H amination of 4-dialkylamino-indole-3-carbaldehydes with primary amines was developed for green synthesis of diazepino[6,5,4- cd ]indoles via cascade aldimine condensation/[1,6]-hydride transfer/cyclization.