Exploring optical coherence tomography parameters in eyes with myopic tilted disc

作者：Yu Qiao Zhang, Xiu Juan Zhang, Rongxu Shen, Yuzhou Zhang, Fang Tang, Simon Szeto, Danny Siu‐Chun Ng, Ka Wai Kam, Alvin L Young, Li Jia Chen, Chi Pui Pang, Clement C. Tham, Jason C. Yam, Poemen P. Chan · 发表于：Eye and Vision · 年份：2024 · DOI：10.1186/s40662-024-00411-3 · 被引用次数：8 · 研究领域：Glaucoma and retinal disorders、Cerebral Venous Sinus Thrombosis、Optical Coherence Tomography Applications

BACKGROUND: To investigate the impact of optic disc torsion (ODT), horizontal disc tilt (HDT) angle, and ovality index (OI) on different retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCIPL) segments in healthy myopic eyes. METHODS: ODT and OI were measured from fundus photographs. HDT angle, peripapillary RNFL, and macular GCIPL were measured by swept-source optical coherence tomography (SS-OCT). The association between optic disc morphology and the RNFL/GCIPL thickness were evaluated, with age and axial length (AL) adjusted. RESULTS: Among 530 healthy myopic eyes of 284 participants (mean age: 41.7 years, mean spherical equivalent: - 7.70 D, and mean AL: 26.6 mm), 335 eyes (63.2%) had temporal disc torsion (temporal group) and 195 eyes (36.8%) had nasal disc torsion (nasal group). For the nasal group, a larger OI was associated with thinner superior-to-superonasal GCIPL (β = - 7.465 to - 6.972, both P = 0.024) and temporal RNFL sectors (β = - 49.596 to - 27.748, P ≤ 0.014). For the temporal group, a larger OI was associated with thinner superior-to-nasal (β = - 50.255 to - 22.093, P ≤ 0.006) and thicker temporal RNFL sectors (β = 29.015 to 56.890, P ≤ 0.003). Additionally, a larger HDT angle was associated with thinner superior-to-nasal RNFL sectors (β = - 0.559 to - 0.242, P ≤ 0.036) and thinner superior-to-superotemporal GCIPL sectors (β = - 0.084 to - 0.069, P ≤ 0.037). CONCLUSIONS: The optic disc tortional direction was associated with the mea...