Efficacy and safety of mirikizumab in patients with moderately-to-severely active Crohn's disease: a phase 3, multicentre, randomised, double-blind, placebo-controlled and active-controlled, treat-through study

作者：Marc Ferrante, Marc Ferrante, Geert D’Haens, Vipul Jairath, Silvio Danese, Minhu Chen, Subrata Ghosh, Tadakazu Hisamatsu, Jaroslaw Kierkus, Britta Siegmund, Sonja M. Bragg, Wallace Crandall, Frédérick Durand, Emily Hon, Zhantao Lin, Michelle Ugolini Lopes, Nathan Morris, Marijana Protić, Hilde Carlier, Bruce E Sands, Emiliano Tron, Fernanda Dorado, Lena Thin, Rupert W. Leong, Hansjoerg Seltenreich, Britt Christensen, Anthony Croft, Simon Ghaly, Robert Koch, Walter Reinisch, Sonja Heeren, Peter Bossuyt, Marc Ferrante, Marc Ferrante, Fabio Luiz Maximiano, Lígia Yukie Sassaki, Carolina Baía, D. Poli, A D S Carlos, Carlos Fernando de Magalhães Francesconi, Alexander De Sa Rolim, J. Razera, Joaquim Simões Neto, Rodrigo Rocco, Jonathas Stifft, Jonathan Soldera, Genoile Silva, C. Clemente, Sandra Di Felice Boratto, Luciana Teixeira de Campos, Marcelo Rodrigues Borba, Gregory Rosenfeld, Terry Ponich, Allen Lim, Chadwick Williams, Bruce Musgrave, S. Gauthier, Wenjia Liu, Chengdang Wang, Hong Guo, Chunxiao Chen, Yan Chen, Qian Cao, Jie Zhong, Min Xu, Yufang Wang, Changqing Zheng, Xiang Gao, Youxiang Chen, Yinglei Miao, Lin Wang, Deliang Liu, Bangmao Wang, Zhengji Song, Xiaowei Liu, Baili Chen, Yi Jiang, Qiang Zhan, Kaiguang Zhang, Hong Shen, Zhaotao Li, Xiaoyan Wang, M Wang, Dean Tian, Leilei Chen, Wen Tang, Vladimir Borzan, Željko Krznarić, Miroslava Volfová, Jiri Pumprla, Lucie Veberova, Michal Tichý, Jan Gregar, David Stepek, Jan Ulbrych, Pavel Drastich, Zdenek Papik, Jan Matouš, Martin Lukáš, Radka Koskova, Jan Fallingborg, Romain Altwegg, Ginette Fotsing, David Laharie, Stéphane Nancey, Laurent Peyrin, Stefan Schreiber, Jörg Hoffmann, Ursula Seidler, Lars Fechner, Katrin Arélin, Christel Contzen, Guido Trenn, Thomas Schaum, Katrin Schoettker, Oliver Bachmann, Jens Encke, Michael Ibe, Christian Jakobeit, Márta Varga, Á Salamon, András Káfony, Gyula Horvat, Zsanett Heringh, Katalin Bezzegh, F Izbéki, L Szalai, Robert Schnabel, Jayanta Samanta, Rupa Banerjee, Ganesh Subramanian, Shrikant Mukewar, Naresh Bansal, Ajit Sood, Ravi Shankar Bagepally, P. Shravan Kumar, Pankaj Shrimal, Saumin Shah, Nitin Pai, Vineet Ahuja, Ehud Melzer, Nimer Assy, Eran Goldin, Haim Shirin, Arik Segal, Adi Lahat, Simone Saibeni, Francesco Luzza, Silvio Danese, Flavio Caprioli, Maria Laura Annunziata, Massimo Claudio Fantini, Koichiro Matsuda, Sho Takagi, Shuji Kanmura, Mitsuhide Goto, Toshifumi Ashida, Nobuaki Nishimata, Kazuhiko Kawakami, Yoh Ishiguro Ishiguro, Atsuo Maemoto, Yuji Naito Naito, Hideaki Naoe, Hiroshi Nakase, Tomohiro Iida, Junichi Akiyama, Masao Yoshioka, Yasuhiko Abe, Ken Takeuchi, Mikio Kawai, Fumihito Hirai, Noriyuki Horiki, Sang Hyoung Park, Dong II Park, Sang‐Bum Kang, Min Kyu Jung, Byung Ik Jang, Yoo Jin Lee, Sung Jae Shin, Tae Oh Kim, Hyun‐Soo Kim, Bo‐In Lee, Jong Hun Lee, Hyo Jong Kim, Chang Hwan Choi, Dongwoo Kim, Chang Soo Eun, Ben Kang, Juris Pokrotnieks, Gediminas Kiudelis, Karina Ramirez, Jose Luis Vega Fonseca, Robert J.F. Laheij, Jaroslaw Kierkus, Maria Kłopocka, Zbigniew Wylegala, Beata Mroziak, Katarzyna Wójcik‐Pszczoła, Bartosz Korczowski, Beata Gawdis, Wit Danilkiewicz, Magdalena Olszanecka, Jolanta Krzykowska, Zofia Jamrozik, Malgorzata Duszynska, Agnieszka Ciesiolkiewicz, Malgorzata Baluta, M. Horyński, Jarosław Leszczyszyn, Grzegorz Rozumek, Lukasz Firkowski, Marzena Konopko, Jakub Orleanski, Rafał Filip, Anna Wiechowska, Krzysztof Niezgoda, Radu Mateescu, Eugeniu Craciun, Camelia Chioncel, Marioara Musat, Theodor Voiosu, В. И. Трофимов, О. Б. Щукина, Anatoly Pershko, Olga Fedorishina, Galina Chumakova, И. Г. Бакулин, М. Ф. Осипенко, D Nikolin, О Б Барышева, Olga Alexeeva, К. А. Захаров, Irina Khodareva, Alexander Tkachev, А. О. Головенко, Veronika Popova, В. Н. Кашников, Maria Vershinina, P. A. Makarchuk, Ekaterina Valuyskikh, Slobodanka Crevar, Petar Svorcan, Tatjana Latinovic Radakovic, Tibor Hlavatý, Ivan Bunganič, Miroslav Fedurco, Iveta Kalisova, Jozef Baláž, Lubomír Mihalkanin, María Dolores Martín‐Arranz, L. de Teresa Parreño, Miquel Sans Cuffi, Alejandro Hernández-Camba, Stephan Brand, Pascal Juillerat, Frank Seibold, Hakan Demirci, Ahmet Tezel, Halis Simsek, Murat Kıyıcı, Can Gönen, Sadettin Hülagü, Tarkan Karakan, Ayhan Hilmi Çekın, Engin Altıntaşž, Kadri Güven, Hale Akpınar, Yasemin Özın, Yusuf Erzın, Mehmet Cihat Demir, Tuncer Temel, Tetiana Lohdanidi, V. Y. Ivanov, Olha Ivanishyn, Oleksandr Golovchenko, О.M. Gerasymenko, S.V. Danyliuk, Vira Vyshyvanyuk, Olena Datsenko, Mykola Stanislavchuk, Yaroslava Rishko, O. Kyrychenko, Dmytro Donets, Yu A Shapovalova, Andriy Yurkiv, Oleksandr Oliinyk, Nataliia Tsarynna, О. І. Федів, Yevgen Poplyonkin, Arthur Kaser, S Hoque, Hawys Thomas, Shalini Iyengar, Frederic Newman, Ronald Fogel, P.C. Pedersen, Chad Gonzales, Gregory S. McCord, Michael Galambos, Paul Lamb, Jeffrey A. Schneider, Bal Raj Bhandari, Michael D. Weiss, Christine Thai, Michael D. Shapiro, Ziad Younes, Narayanachar Murali, Jason Hou, Todd Williams, Omer Khalid, Connie Hsu, Christopher R. Bartalos, Calin Arimie, Syed Mumtaz, Israel Crespo, Renée M. Marchioni Beery, Anne Tuskey, Ryan Gaible, Alan F. Cutler, Anita Afzali, Kevin Stuart, Eric Ibegbu, Moises Irizarry-Roman, Kimberly A. Harris, Kwadwo Agyei, Frances Jones, Aasim Sheikh, Liam Zakko, Erica Cohen, George Duvall, Houssam Al Kharrat, Robert Wohlman, William Holderman, Alan Schulman, Sheldon Lidofsky, Peter M. Wayne, Luis Victores, Christian D. Stone, Kenolisa Onwueme, Monika Fischer, Shabana Shahid, Keith Moore, Jeffry Katz, James S. Bullock, Julien Fahed · 发表于：The Lancet · 年份：2024 · DOI：10.1016/s0140-6736(24)01762-8 · 被引用次数：107 · 研究领域：Inflammatory Bowel Disease、Rheumatoid Arthritis Research and Therapies、Liver Diseases and Immunity