Antigenicity and genetic properties of an Eurasian avian-like H1N1 swine influenza virus in Jiangsu Province, China

作者：Fang He, Huiyan Yu, Liqi Liu, Xiyan Li, Yadong Xing, Lei Yang, Pengfei Yang, Liguo Zhu, Zi Li · 发表于：Biosafety and Health · 年份：2024 · DOI：10.1016/j.bsheal.2024.11.007 · 被引用次数：7 · 研究领域：Influenza Virus Research Studies、Animal Disease Management and Epidemiology、Viral gastroenteritis research and epidemiology

• Scientific question Cross-species transmission of influenza A viruses from swine to humans occurs occasionally because their tracheal epitheliums possess both sialic acid α-2,6-Gal and α-2,3-Gal receptors. In 2011, the first human case of swine influenza virus infection in the mainland of China was detected in Jiangsu Province. Subsequently, the Eurasian avian-like H1N1 swine influenza virus (EAH1N1 SIV) had sporadically crossed the host barrier and infected humans, raising public concern for its pandemic potential. • Evidence before this study A/Jiangsu/1/2011 (H1N1v) was first discovered in 2011 and belongs to the G1 genotype. The G4 and G5 genotypes that appeared successively in 2013 are recombinant H1N1 swine influenza viruses. The EAH1N1 SIVs from 2016 to the present are dominated by the G4 genotype, with hemagglutination (HA) and neuraminidase (NA) genes derived from the EAH1N1 SIVs, non-structural protein (NS) genes derived from the triple-origin reassortant swine influenza viruses, and the rest of the internal genes from influenza A (H1N1) pdm09 virus. • New findings This study investigated a case of the EAH1N1 SIV infection in a child. This is the first case of the EAH1N1 SIV genotype G4 infection in a child in Jiangsu Province. This virus maintained the genetic properties of the EAH1N1 SIV but differed significantly in HA protein antigens. • Significance of the study This new human case of the EAH1N1 SIV infection indicates the pandemic potential of avian influenz...