A Bicyclic Dioxetane Chemiluminescence Nanoprobe for Peroxynitrite Imaging in Vivo

作者：Min Shi, Yun Zhang, Jia-Xing Chen, Yanyuan Wu, Zongping Wang, Pengfei Shi, Xudong Jin, Xue‐Qiang Wang · 发表于：Analytical Chemistry · 年份：2024 · DOI：10.1021/acs.analchem.4c04510 · 被引用次数：8 · 研究领域：Nanoplatforms for cancer theranostics、Advanced Nanomaterials in Catalysis、Advanced biosensing and bioanalysis techniques

Peroxynitrite (ONOO – ) is a critical biomarker associated with a wide array of diseases including cancer, inflammatory conditions, and neurodegenerative disorders. This study introduces an innovative chemiluminescence nanoprobe (CLNP) based on a bicyclic dioxetane structure, designed for highly sensitive and specific in vivo imaging of ONOO – . Our CLNP demonstrates exceptional capabilities in generating high-contrast imaging of disease lesions, with applications verified across tumor models, acute inflammation, and acute liver injury scenarios. Key findings highlight the probe’s rapid response to oxidative species, superior tissue penetration, and high signal-to-noise ratio, underscoring its potential for real-time diagnostic applications. This work represents an important advance in the field of diagnostic imaging using CL probes, offering promising avenues for the early detection and treatment of ONOO – -related pathologies.