Grape seed proanthocyanidins improves growth performance, antioxidative capacity, and intestinal microbiota in growing pigs
作者：Yuyang Zheng, Yan Li, Bing Yu, Zhiqing Huang, Yuheng Luo, Ping Zheng, Xiangbing Mao, Jie Yu, H Tan, Junqiu Luo, Hui Yan, Jun He · 发表于：Frontiers in Microbiology · 年份：2024 · DOI：10.3389/fmicb.2024.1501211 · 被引用次数：8 · 研究领域：Animal Nutrition and Physiology、Meat and Animal Product Quality、Gut microbiota and health
Grape seed proanthocyanidin (GSP) is a kind of plant polyphenols with a wide variety of biological activities. In this study, we explored the effect of dietary GSP supplementation on growth performance, nutrient digestibility, and intestinal microbiota in growing pigs. A total of 180 growing pigs (30.37 ± 0.31 kg) were randomly assigned to five treatment groups, each consisting of six replicate pens with six pigs per pen. The pigs received either a basal diet (control) or a basal diet supplemented with GSP at 15, 30, 60, or 120 mg/kg. The trial lasted for 33 days, and blood and fecal samples were collected for biochemical measurements. GSP supplementation at a dose from 30 to 120 mg/kg decreased the ratio of feed intake to gain ( F : G ) ( p < 0.05). GSP also increased the digestibility of dry matter, crude protein, ether extract, and gross energy ( p < 0.05). GSP supplementation at 30 mg/kg increased the serum concentrations of immunoglobulin (Ig) A ( p < 0.05). Interestingly, GSP supplementation at 60 mg/kg decreased the serum concentrations of urea and malondialdehyde ( p < 0.05). However, the serum concentrations of glutathione peroxidase and total superoxide dismutase were significantly increased upon GSP supplementation ( p < 0.05). Importantly, GSP supplementation at 120 mg/kg significantly increased the abundance of the phylum Firmicutes, but decreased the abundance of phylum Bacteroidetes and Epsilonbacteraeota in the feces ( p &...