Allylation of Lactol in Water

作者：Mengxue Zheng, Wenxiu Gao, Lei Zhang, Kaiyu Yan, Zhenguo Zhang, Peizhong Xie, Teck‐Peng Loh · 发表于：Organic Letters · 年份：2024 · DOI：10.1021/acs.orglett.4c04189 · 被引用次数：3 · 研究领域：Chemical Synthesis and Reactions、Chemical Synthesis and Analysis、Analytical Chemistry and Chromatography

We developed a water-promoted cross-coupling of 3-hydroxyisobenzofuran-1(3 H )-ones and allylic boronates under biocompatible conditions. This approach facilitates the synthesis of diverse 3-allylic phthalides with high yields and exceptional selectivity in a metal-free manner. The versatility and practicality of this protocol underscore its significant potential for drug development and applications in medicinal chemistry.