Phthalate exposures, blood coagulation function, and assisted reproductive technology outcomes: Results from the TREE cohort study

作者：Chong Liu, Changjiang Liu, Wenqu Tian, Wen Yao, Miao Yu, Min Zhang, Xiao-Qiong Yuan, Yan-Ling Deng, Wen‐Qing Lu, Yufeng Li, Qiang Zeng · 发表于：Environmental Research · 年份：2024 · DOI：10.1016/j.envres.2024.120412 · 被引用次数：5 · 研究领域：Effects and risks of endocrine disrupting chemicals、Ovarian function and disorders、Pharmacological Effects and Toxicity Studies

BACKGROUND: Phthalate exposures have been shown to be inversely associated with reproductive success among women undergoing assisted reproductive technology (ART). However, the underlying mechanisms are unknown. OBJECTIVES: To explore blood coagulation function as the mediating role of associations between exposure to phthalates and ART outcomes. METHODS: A total of 735 women from the Tongji Reproductive and Environmental (TREE) study were included. Urine samples collected at recruitment were quantified for 8 phthalate metabolites, and blood clotting time and platelet indices were also determined. Generalized linear regression, logistic regression, weighted quantile sum (WQS) regression, or Bayesian kernel machine regression (BKMR) models were applied to investigate the associations among individual and mixture of phthalate metabolites, blood coagulation parameters, and ART outcomes. The mediation role of blood coagulation parameters was estimated by mediation analysis. RESULTS: Mono-n-butyl phthalate (MBP), mono-isobutyl phthalate (MiBP), monobenzyl phthalate (MBzP), mono(2-ethyl-5-carboxypentyl) phthalate (MECPP), and molar sum of di(2-ethylhexyl) phthalate metabolites (∑DEHP) were positively associated with platelet indices. Phthalate metabolite mixture was also positively associated with platelet count (PLT), mean platelet volume (MPV), and plateletcrit (PCT), whereas inversely associated with international normalized ratio (INR). Meanwhile, PLT and PCT were inversely ass...