Plasma Glial Fibrillary Acid Protein and Phosphorated Tau 181 Association with Presynaptic Density-Dependent Tau Pathology at 18F-SynVesT-1 Brain PET Imaging

作者：Junhao Wu, Binyin Li, Jie Wang, Qi Huang, Xing Chen, Zhiwen You, Kun He, Qihao Guo, Songye Li, Yiyun Huang, Tengfei Guo, Wenlin Dai, Wei‐Wei Xiang, Weihuang Chen, Dake Yang, Jun Zhao, Yihui Guan, Fang Xie · 发表于：Radiology · 年份：2024 · DOI：10.1148/radiol.233019 · 被引用次数：18 · 研究领域：Alzheimer's disease research and treatments、Neuroscience and Neuropharmacology Research、Medical Imaging Techniques and Applications

Plasma phosphorylated tau 181 (p-tau-181) and glial fibrillary acidic protein (GFAP) have potential predictive value for identifying synaptic density as measured using 18 F-SynVesT-1 brain PET; the relationship of plasma p-tau-181 and GFAP with synapse loss might be influenced by tau aggregation rather than amyloid-β deposition or cortical thickness.