Global, regional, and national burden of dengue infection in children and adolescents: an analysis of the Global Burden of Disease Study 2021

作者：Jie Deng, Hui Zhang, Yaping Wang, Qiao Liu, Min Du, Wenxin Yan, Chenyuan Qin, Shimo Zhang, Weiyang Chen, Liyan Zhou, Min Liu, Ben Niu, Jue Liu · 发表于：EClinicalMedicine · 年份：2024 · DOI：10.1016/j.eclinm.2024.102943 · 被引用次数：47 · 研究领域：Mosquito-borne diseases and control、Viral Infections and Outbreaks Research、Health, Environment, Cognitive Aging

Background: Dengue remains a global threat to public health, however, its disease burden among children and adolescents has always been poorly quantified. Therefore, we aimed to systematically estimate the global, regional, and national burden and temporal trends of dengue infection in children and adolescents from 1990 to 2021. Methods: Data on the number and rate of incidence and disability-adjusted life-years (DALYs) of dengue infection among children and adolescents under 20 years were obtained from the Global Burden of Disease Study (GBD) 2021. Estimated annual percentage changes (EAPCs) of the age-standardised incidence rate (ASIR) and age-standardised DALYs rate (ASDR), by age, sex, and different countries and regions, were calculated to quantify the temporal trends of dengue burden. The association between development levels (measured using the socio-demographic index [SDI]) and dengue burden was also determined. Findings: From 1990 to 2021, the global burden of dengue incidence and its associated DALYs was consistently higher in children and adolescents than in the entire population. Globally, among children and adolescents, there were 21,641,016 incident cases in 2021, an increase of 64.43% compared to 13,241,719 in 1990. The ASIR per 100,000 population increased from 587.81 in 1990 to 812.16 in 2021, with an EAPC of 1.39% (95% confidence interval [CI], 1.13%-1.65%). Besides, the number of dengue-associated DALYs among children and adolescents increased by 16.36%, f...