Bidirectional associations among gallstone disease, non-alcoholic fatty liver disease, kidney stone disease

作者：Gengru Jiang, Sheng Li, Hongyu Li, Linjun Xie, Shiyi Li, Zi-Tong Yan, Wenqian Yu, Jing Luo, Xuan Bai, Lingxi Kong, Yanmei Lou, Chi Zhang, Guang-Can Li, Xue‐Feng Shan, Min Mao, Xin Wang · 发表于：World Journal of Gastroenterology · 年份：2024 · DOI：10.3748/wjg.v30.i46.4914 · 被引用次数：8 · 研究领域：Gallbladder and Bile Duct Disorders、Kidney Stones and Urolithiasis Treatments、Omental and Epiploic Conditions

BACKGROUND: A body of evidence has suggested bidirectional relationships among gallstone disease (GSD), non-alcoholic fatty liver disease (NAFLD), and kidney stone disease (KSD). However, the results are inconsistent, and studies on this topic in China are relatively few. Our goal is to explore the bidirectional associations among these three diseases through a multicenter study, systematic review, and meta-analysis. AIM: To explore the bidirectional associations among these three diseases through a multicenter study, systematic review, and meta-analysis. The results may help to investigate the etiology of these diseases and shed light on the individualized prevention of these three diseases. METHODS: Subjects who participated in physical examinations in Beijing, Tianjin, Chongqing in China were recruited. Multivariable logistic regression was employed to explore the bidirectional relationships among GSD, KSD, and NAFLD. Systematic review and meta-analysis were initiated to confirm the epidemiologic evidence from previous observational studies. Furthermore, trial sequential analysis (TSA) was conducted to evaluate whether the evidence was sufficient and conclusive. RESULTS: Significant bidirectional associations were detected among the three diseases, independent of potential confounding factors. The pooled results of the systematic review and meta-analysis also corroborated the aforementioned results. The combined evidence from the multicenter study and meta-analysis was sig...